(1R)-1-(1-acetyl-7-methoxy-2,3-dihydro-1H-inden-1-yl)-3-phenylthio-2-propynyl 2-benzyloxy-4,5-dimethoxybenzoate

Base Information

Chemical Name:(1R)-1-(1-acetyl-7-methoxy-2,3-dihydro-1H-inden-1-yl)-3-phenylthio-2-propynyl 2-benzyloxy-4,5-dimethoxybenzoate
CAS No.:872188-33-5
Molecular Formula:C₃₇H₃₄O₇S
Molecular Weight:622.739
Hs Code.:

Synonyms:(1R)-1-(1-acetyl-7-methoxy-2,3-dihydro-1H-inden-1-yl)-3-phenylthio-2-propynyl 2-benzyloxy-4,5-dimethoxybenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-1-(1-acetyl-7-methoxy-2,3-dihydro-1H-inden-1-yl)-3-phenylthio-2-propynyl 2-benzyloxy-4,5-dimethoxybenzoate

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Technology Process of (1R)-1-(1-acetyl-7-methoxy-2,3-dihydro-1H-inden-1-yl)-3-phenylthio-2-propynyl 2-benzyloxy-4,5-dimethoxybenzoate

There total 11 articles about (1R)-1-(1-acetyl-7-methoxy-2,3-dihydro-1H-inden-1-yl)-3-phenylthio-2-propynyl 2-benzyloxy-4,5-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: (1R)-1-acetyl-1-(1'-hydroxy-3'-phenylthio-2'-propynyl)-7-methoxy-2,3-dihydro-1H-indene

: 317350-40-6
2-Benzyloxy-4,5-dimethoxybenzoyl chloride

: 872188-33-5
(1R)-1-(1-acetyl-7-methoxy-2,3-dihydro-1H-inden-1-yl)-3-phenylthio-2-propynyl 2-benzyloxy-4,5-dimethoxybenzoate

Guidance literature:: With dmap; In dichloromethane; at 0 - 20 ℃;
DOI:10.1002/chem.200500443

Reference yield: 56.0%

: 6228-98-4
phenylthioacetylene

: 317350-40-6
2-Benzyloxy-4,5-dimethoxybenzoyl chloride

: 391859-13-5
(R)-1-Acetyl-7-methoxy-indan-1-carbaldehyde

: 872188-33-5
(1R)-1-(1-acetyl-7-methoxy-2,3-dihydro-1H-inden-1-yl)-3-phenylthio-2-propynyl 2-benzyloxy-4,5-dimethoxybenzoate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 3h;
DOI:10.1002/chem.200500443

Reference yield:

: 317350-56-4
2-benzyloxy-4,5-dimethoxybenzoic acid

: 872188-33-5
(1R)-1-(1-acetyl-7-methoxy-2,3-dihydro-1H-inden-1-yl)-3-phenylthio-2-propynyl 2-benzyloxy-4,5-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂ / 0 - 20 °C

2: 56 percent / LiN(TMS)2 / tetrahydrofuran / 3 h / -78 °C

With thionyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.200500443