(2'R,4Z)-1-((diphenylmethylene)amino)-3-(tert-butyl-3'-phenyl-2'-propanoate)-4-(p-fluorobenzylidene)imidazolidin-2-one

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Chemical Name:(2'R,4Z)-1-((diphenylmethylene)amino)-3-(tert-butyl-3'-phenyl-2'-propanoate)-4-(p-fluorobenzylidene)imidazolidin-2-one
CAS No.:1392506-55-6
Molecular Formula:C₃₆H₃₄FN₃O₃
Molecular Weight:575.683
Hs Code.:

Synonyms:(2'R,4Z)-1-((diphenylmethylene)amino)-3-(tert-butyl-3'-phenyl-2'-propanoate)-4-(p-fluorobenzylidene)imidazolidin-2-one

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Chemical Property of (2'R,4Z)-1-((diphenylmethylene)amino)-3-(tert-butyl-3'-phenyl-2'-propanoate)-4-(p-fluorobenzylidene)imidazolidin-2-one

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Technology Process of (2'R,4Z)-1-((diphenylmethylene)amino)-3-(tert-butyl-3'-phenyl-2'-propanoate)-4-(p-fluorobenzylidene)imidazolidin-2-one

There total 2 articles about (2'R,4Z)-1-((diphenylmethylene)amino)-3-(tert-butyl-3'-phenyl-2'-propanoate)-4-(p-fluorobenzylidene)imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1392506-49-8
benzhydrylidene aza-p-fluorophenylpropargylglycinyl-D-phenylalanine tert-butyl ester

: 1392506-55-6
(2'R,4Z)-1-((diphenylmethylene)amino)-3-(tert-butyl-3'-phenyl-2'-propanoate)-4-(p-fluorobenzylidene)imidazolidin-2-one

Guidance literature:: With sodium hydride; In acetonitrile; mineral oil; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol302021n

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 1392506-36-3
tert-butyl (2-(diphenylmethylene)-1-(prop-2-yn-1-yl)hydrazine-1-carbonyl)-D-phenylalaninate

: 1392506-55-6
(2'R,4Z)-1-((diphenylmethylene)amino)-3-(tert-butyl-3'-phenyl-2'-propanoate)-4-(p-fluorobenzylidene)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 12 h / Inert atmosphere

2: sodium hydride / acetonitrile; mineral oil / 12 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; diethylamine; In N,N-dimethyl-formamide; acetonitrile; mineral oil; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/ol302021n