1-({3'-chloro-3-fluoro-6'-methoxy-2'-methyl-5'-[1-(9H-purin-6-ylamino)ethyl]biphenyl-4-yl}carbonyl)azetidine-3-carbonitrile

Base Information

Chemical Name:1-({3'-chloro-3-fluoro-6'-methoxy-2'-methyl-5'-[1-(9H-purin-6-ylamino)ethyl]biphenyl-4-yl}carbonyl)azetidine-3-carbonitrile
CAS No.:1382993-45-4
Molecular Formula:C₂₆H₂₃ClFN₇O₂
Molecular Weight:519.966
Hs Code.:

Synonyms:1-({3'-chloro-3-fluoro-6'-methoxy-2'-methyl-5'-[1-(9H-purin-6-ylamino)ethyl]biphenyl-4-yl}carbonyl)azetidine-3-carbonitrile

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Chemical Property of 1-({3'-chloro-3-fluoro-6'-methoxy-2'-methyl-5'-[1-(9H-purin-6-ylamino)ethyl]biphenyl-4-yl}carbonyl)azetidine-3-carbonitrile

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Technology Process of 1-({3'-chloro-3-fluoro-6'-methoxy-2'-methyl-5'-[1-(9H-purin-6-ylamino)ethyl]biphenyl-4-yl}carbonyl)azetidine-3-carbonitrile

There total 6 articles about 1-({3'-chloro-3-fluoro-6'-methoxy-2'-methyl-5'-[1-(9H-purin-6-ylamino)ethyl]biphenyl-4-yl}carbonyl)azetidine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382995-47-2
1-{[3'-(1-aminoethyl)-5'-chloro-3-fluoro-2'-methoxy-6'-methylbiphenyl-4-yl]carbonyl}azetidine-3-carbonitrile

: 767-69-1
6-bromopurine

: 1382993-45-4
1-({3'-chloro-3-fluoro-6'-methoxy-2'-methyl-5'-[1-(9H-purin-6-ylamino)ethyl]biphenyl-4-yl}carbonyl)azetidine-3-carbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 90 ℃; Inert atmosphere;

Reference yield:

: 1382994-99-1
1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethanone

: 1382993-45-4
1-({3'-chloro-3-fluoro-6'-methoxy-2'-methyl-5'-[1-(9H-purin-6-ylamino)ethyl]biphenyl-4-yl}carbonyl)azetidine-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / 1,4-dioxane; water / 100 °C / Inert atmosphere

2: water; sodium hydroxide / methanol / 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

4: methanol; ammonium acetate; sodium cyanoborohydride / acetonitrile / 65 °C / Sealed tube

5: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 90 °C / Inert atmosphere

With methanol; ammonium acetate; water; sodium cyanoborohydride; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1382995-42-7
methyl 3'-acetyl-5'-chloro-3-fluoro-2'-methoxy-6'-methylbiphenyl-4-carboxylate

: 1382993-45-4
1-({3'-chloro-3-fluoro-6'-methoxy-2'-methyl-5'-[1-(9H-purin-6-ylamino)ethyl]biphenyl-4-yl}carbonyl)azetidine-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: water; sodium hydroxide / methanol / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

3: methanol; ammonium acetate; sodium cyanoborohydride / acetonitrile / 65 °C / Sealed tube

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 90 °C / Inert atmosphere

With methanol; ammonium acetate; water; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;