-D-phenylalanine (methoxyethoxy)methyl ester O-

Base Information

Chemical Name:-D-phenylalanine (methoxyethoxy)methyl ester O-
CAS No.:159579-69-8
Molecular Formula:C₄₆H₅₅N₃O₁₄
Molecular Weight:873.954
Hs Code.:

<N-(tert-Butoxycarbonyl)-(R)-3-hydroxy-4-methoxyphenylglycinyl>-D-phenylalanine (methoxyethoxy)methyl ester O-<N-(benzyloxycarbonyl)-(S)-2-methyl-3-methoxyphenylglycine methyl ester>

Synonyms:-D-phenylalanine (methoxyethoxy)methyl ester O-

Suppliers and Price of -D-phenylalanine (methoxyethoxy)methyl ester O-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of -D-phenylalanine (methoxyethoxy)methyl ester O-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of -D-phenylalanine (methoxyethoxy)methyl ester O-

There total 1 articles about -D-phenylalanine (methoxyethoxy)methyl ester O- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.7%

: 109838-85-9
(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

: 501-53-1,94274-21-2
benzyl chloroformate

: 159579-66-5
2(R)-<<(1,1-Dimethylethoxy)carbonyl>amino>-2-<(3-hydroxy-4-methoxyphenyl)acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

: (R)-2-{(R)-2-tert-Butoxycarbonylamino-2-[4-methoxy-3-(3-methoxy-2-methyl-phenoxy)-phenyl]-acetylamino}-3-phenyl-propionic acid 2-methoxy-ethoxymethyl ester

: C₄₆H₅₅N₃O₁₄

: 159579-69-8
-D-phenylalanine (methoxyethoxy)methyl ester O-

: C₄₆H₅₅N₃O₁₄

Guidance literature:: With sodium carbonate; In diethyl ether; at 0 ℃; for 0.2h; Further byproducts given. Yields of byproduct given;
DOI:10.1021/jo00088a010

Reference yield: 82.0%

: 159579-69-8
-D-phenylalanine (methoxyethoxy)methyl ester O-

: 159579-70-1
-D-phenylalanine O-

Guidance literature:: With magnesium bromide; In diethyl ether; for 26h; Ambient temperature;
DOI:10.1021/jo00088a010

Reference yield:

: 159579-69-8
-D-phenylalanine (methoxyethoxy)methyl ester O-

: (8S,11R,14R)-11-Benzyl-14-tert-butoxycarbonylamino-5,18-dimethoxy-4-methyl-10,13-dioxo-2-oxa-9,12-diaza-tricyclo[13.3.1.1^3,7]icosa-1⁽¹⁸⁾,3⁽²⁰⁾,4,6,15⁽¹⁹⁾,16-hexaene-8-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / MgBr₂*Et₂O / diethyl ether / 26 h / Ambient temperature

2: H₂ / 10percent Pd-C / ethanol / 1 h

3: EDC, HOBT / CH₂Cl₂ / 1.) 0 deg C, 4 h, 2.) room temp., 12 h

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; magnesium bromide; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo00088a010