N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide

Base Information

Chemical Name:N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide
CAS No.:337534-84-6
Molecular Formula:C₂₁H₂₁N₃O₂
Molecular Weight:347.417
Hs Code.:

Synonyms:N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide

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Chemical Property of N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide

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Technology Process of N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide

There total 5 articles about N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 337535-65-6
N-[4'-[cyclopropyl(hydroxy)(1-trityl-1H-imidazol-4-yl)methyl][1,1'-biphenyl]-3-yl]acetamide

: 337534-84-6
N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide

Guidance literature:: With pyridine hydrochloride; In methanol; at 60 ℃; for 4h;
DOI:10.1016/j.bmc.2011.02.009

Reference yield:

: 337535-62-3
(4-bromophenyl)(1-trityl-1H-imidazol-4-yl)methanone

: 337534-84-6
N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 18 h / Reflux; Inert atmosphere

2: tetrahydrofuran / 0.33 h / 0 °C

3: pyridine hydrochloride / methanol / 4 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridine hydrochloride; sodium carbonate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; 1: Suzuki coupling / 2: Grignard reaction;
DOI:10.1016/j.bmc.2011.02.009

Reference yield:

: 337535-63-4
N-[4'-[(1-trityl-1H-imidazol-4-yl)carbonyl][1,1'-biphenyl]-3-yl]acetamide

: 337534-84-6
N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.33 h / 0 °C

2: pyridine hydrochloride / methanol / 4 h / 60 °C

With pyridine hydrochloride; In tetrahydrofuran; methanol; 1: Grignard reaction;
DOI:10.1016/j.bmc.2011.02.009