2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(pyrimidin-4-yl)-6-(trifluoromethyl)phenyl]acetic acid

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Chemical Name:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(pyrimidin-4-yl)-6-(trifluoromethyl)phenyl]acetic acid
CAS No.:1596341-29-5
Molecular Formula:C₂₆H₂₅F₃N₂O₄
Molecular Weight:486.491
Hs Code.:

Synonyms:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(pyrimidin-4-yl)-6-(trifluoromethyl)phenyl]acetic acid

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Chemical Property of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(pyrimidin-4-yl)-6-(trifluoromethyl)phenyl]acetic acid

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Technology Process of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(pyrimidin-4-yl)-6-(trifluoromethyl)phenyl]acetic acid

There total 16 articles about 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(pyrimidin-4-yl)-6-(trifluoromethyl)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1596341-67-1
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(pyrimidin-4-yl)-6-(trifluoromethyl) phenyl]acetate

: 1596341-29-5
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(pyrimidin-4-yl)-6-(trifluoromethyl)phenyl]acetic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; water; at 110 ℃; for 18h;

Reference yield:

: 1596341-66-0
methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)phenyl]acetate

: 1596341-29-5
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(pyrimidin-4-yl)-6-(trifluoromethyl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / 1,4-dioxane; water / 0.33 h / 20 °C / Inert atmosphere

1.2: 72 h / 80 °C / Inert atmosphere

2.1: lithium hydroxide / 1,4-dioxane; water / 18 h / 110 °C

With sodium carbonate; lithium hydroxide; In 1,4-dioxane; water;

Reference yield:

: 1403382-20-6
ethyl 2-[3-fluoro-2-(methoxymethoxy)-6-(trifluoromethyl)phenyl]-2-oxoacetate

: 1596341-29-5
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(pyrimidin-4-yl)-6-(trifluoromethyl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

2.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 85 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

4.2: 3 h / 0 - 60 °C / Inert atmosphere

5.1: methanol / cyclohexane; diethyl ether / 0.5 h / 0 - 20 °C

6.1: sodium tetrahydroborate / tetrahydrofuran / 1.5 h / 0 °C

7.1: perchloric acid / water / 2 h / 0 - 20 °C / Inert atmosphere

8.1: hydrogen; palladium on activated charcoal / ethyl acetate / 40 °C

9.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

10.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 46 h / 80 °C / Inert atmosphere

11.1: sodium carbonate / 1,4-dioxane; water / 0.33 h / 20 °C / Inert atmosphere

11.2: 72 h / 80 °C / Inert atmosphere

12.1: lithium hydroxide / 1,4-dioxane; water / 18 h / 110 °C

With methanol; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; perchloric acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; hydrogen; potassium acetate; sodium hydride; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; cyclohexane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;