(5-Methoxy-benzothiazol-2-ylmethyl)-{5-[4-(6-methoxy-pyridin-3-yl)-2,6-dimethyl-phenyl]-[1,2,4]triazin-3-yl}-amine

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Chemical Name:(5-Methoxy-benzothiazol-2-ylmethyl)-{5-[4-(6-methoxy-pyridin-3-yl)-2,6-dimethyl-phenyl]-[1,2,4]triazin-3-yl}-amine
CAS No.:1203604-76-5
Molecular Formula:C₂₆H₂₄N₆O₂S
Molecular Weight:484.582
Hs Code.:

Synonyms:(5-Methoxy-benzothiazol-2-ylmethyl)-{5-[4-(6-methoxy-pyridin-3-yl)-2,6-dimethyl-phenyl]-[1,2,4]triazin-3-yl}-amine

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Chemical Property of (5-Methoxy-benzothiazol-2-ylmethyl)-{5-[4-(6-methoxy-pyridin-3-yl)-2,6-dimethyl-phenyl]-[1,2,4]triazin-3-yl}-amine

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Technology Process of (5-Methoxy-benzothiazol-2-ylmethyl)-{5-[4-(6-methoxy-pyridin-3-yl)-2,6-dimethyl-phenyl]-[1,2,4]triazin-3-yl}-amine

There total 9 articles about (5-Methoxy-benzothiazol-2-ylmethyl)-{5-[4-(6-methoxy-pyridin-3-yl)-2,6-dimethyl-phenyl]-[1,2,4]triazin-3-yl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1203604-04-9
5-(4-Bromo-2,6-dimethylphenyl)-N-[(5-methoxy-1,3-benzothiazol-2-yl)methyl]-1,2,4-triazin-3-amine

: 163105-89-3,600726-67-8
2-methoxy-pyridine-5-boronic acid

: 1203604-76-5
(5-Methoxy-benzothiazol-2-ylmethyl)-{5-[4-(6-methoxy-pyridin-3-yl)-2,6-dimethyl-phenyl]-[1,2,4]triazin-3-yl}-amine

Guidance literature:: With caesium carbonate; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; In 1,2-dimethoxyethane; water; at 85 ℃; for 72h; Inert atmosphere;

Reference yield:

: 854059-90-8
5-methoxybenzothiazole-2-carboxaldehyde

: 1203604-76-5
(5-Methoxy-benzothiazol-2-ylmethyl)-{5-[4-(6-methoxy-pyridin-3-yl)-2,6-dimethyl-phenyl]-[1,2,4]triazin-3-yl}-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate; hydroxylamine hydrochloride / ethanol / 20 °C / Inert atmosphere

2.1: acetic acid; zinc / 3 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 - 85 °C / Inert atmosphere

4.1: PdCl₂(dppf)2*CHCl₃; caesium carbonate / water; 1,2-dimethoxyethane / 72 h / 85 °C / Inert atmosphere

With PdCl₂(dppf)2*CHCl₃; hydroxylamine hydrochloride; sodium methylate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In 1,2-dimethoxyethane; ethanol; water; acetonitrile; 4.1: |Suzuki Coupling;
DOI:10.1021/jm301499r

Reference yield:

: 1203605-11-1
5-methoxy-1,3-benzothiazole-2-carbaldehyde oxime

: 1203604-76-5
(5-Methoxy-benzothiazol-2-ylmethyl)-{5-[4-(6-methoxy-pyridin-3-yl)-2,6-dimethyl-phenyl]-[1,2,4]triazin-3-yl}-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; zinc / 3 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 - 85 °C / Inert atmosphere

3.1: PdCl₂(dppf)2*CHCl₃; caesium carbonate / water; 1,2-dimethoxyethane / 72 h / 85 °C / Inert atmosphere

With PdCl₂(dppf)2*CHCl₃; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In 1,2-dimethoxyethane; water; acetonitrile; 3.1: |Suzuki Coupling;
DOI:10.1021/jm301499r