1-benzyl-3-fluoro-4-hydroxymethyl-1,2,5,6-tetrahydropyridine hydrochloride

Base Information

Chemical Name:1-benzyl-3-fluoro-4-hydroxymethyl-1,2,5,6-tetrahydropyridine hydrochloride
CAS No.:895578-01-5
Molecular Formula:C₁₃H₁₆FNO*ClH
Molecular Weight:257.735
Hs Code.:

Synonyms:1-benzyl-3-fluoro-4-hydroxymethyl-1,2,5,6-tetrahydropyridine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzyl-3-fluoro-4-hydroxymethyl-1,2,5,6-tetrahydropyridine hydrochloride

Chemical Property:

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Technology Process of 1-benzyl-3-fluoro-4-hydroxymethyl-1,2,5,6-tetrahydropyridine hydrochloride

There total 4 articles about 1-benzyl-3-fluoro-4-hydroxymethyl-1,2,5,6-tetrahydropyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 895578-00-4
1-benzyl-3-fluoro-4-(hydroxymethyl)pyridin-1-ium bromide

: 895578-01-5
1-benzyl-3-fluoro-4-hydroxymethyl-1,2,5,6-tetrahydropyridine hydrochloride

Guidance literature:: 1-benzyl-3-fluoro-4-(hydroxymethyl)pyridin-1-ium bromide; With sodium tetrahydroborate; water; In methanol; at 0 - 20 ℃; Large scale;

With hydrogenchloride; In 1,4-dioxane; methanol; Isopropyl acetate; at 20 - 50 ℃; Large scale;

Reference yield:

: 895578-02-6
1-benzyl-3-fluoro-4-hydroxymethyl-1,2,5,6-tetrahydropyridine

: 895578-01-5
1-benzyl-3-fluoro-4-hydroxymethyl-1,2,5,6-tetrahydropyridine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; Isopropyl acetate; Inert atmosphere;
DOI:10.1016/j.tet.2009.06.105

Reference yield:

: 870063-60-8
3-fluoro-4-(hydroxymethyl)pyridine

: 895578-01-5
1-benzyl-3-fluoro-4-hydroxymethyl-1,2,5,6-tetrahydropyridine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetone / Reflux; Large scale

2.1: sodium tetrahydroborate; water / methanol / 0 - 20 °C / Large scale

2.2: 50 °C / Large scale

With sodium tetrahydroborate; water; In methanol; acetone;