Technology Process of C40H40N4O12S
There total 4 articles about C40H40N4O12S which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-p-nitrobenzyloxycarbonyl-D-cysteine p-nitrobenzyl ester; (R)-β-bromo-N-(fluoren-9-ylmethoxycarbonyl)alanine tert-butyl ester;
With
tetrabutylammomium bromide; sodium hydrogencarbonate;
In
water; ethyl acetate;
for 5h;
pH=8.5;
Inert atmosphere;
With
tributylphosphine;
In
water; ethyl acetate;
for 15h;
Inert atmosphere;
DOI:10.1021/ja4014024
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 21 h / Inert atmosphere
2.1: chlorotriisopropylsilane; trifluoroacetic acid / dichloromethane / 1.5 h / Inert atmosphere
3.1: sodium hydrogencarbonate; tetrabutylammomium bromide / water; ethyl acetate / 5 h / pH 8.5 / Inert atmosphere
3.2: 15 h / Inert atmosphere
With
chlorotriisopropylsilane; tetrabutylammomium bromide; sodium hydrogencarbonate; trifluoroacetic acid;
In
dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja4014024
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: chlorotriisopropylsilane; trifluoroacetic acid / dichloromethane / 1.5 h / Inert atmosphere
2.1: sodium hydrogencarbonate; tetrabutylammomium bromide / water; ethyl acetate / 5 h / pH 8.5 / Inert atmosphere
2.2: 15 h / Inert atmosphere
With
chlorotriisopropylsilane; tetrabutylammomium bromide; sodium hydrogencarbonate; trifluoroacetic acid;
In
dichloromethane; water; ethyl acetate;
DOI:10.1021/ja4014024
