(+)-[2S-(2R,3S,4S*)]-5-hydroxy-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N-2,4-trimethylpentanamide

Base Information

Chemical Name:(+)-[2S-(2R*,3S*,4S*)]-5-hydroxy-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N-2,4-trimethylpentanamide
CAS No.:151058-22-9
Molecular Formula:C₁₇H₂₇NO₅
Molecular Weight:325.405
Hs Code.:

Synonyms:(+)-[2S-(2R*,3S*,4S*)]-5-hydroxy-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N-2,4-trimethylpentanamide

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Chemical Property of (+)-[2S-(2R*,3S*,4S*)]-5-hydroxy-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N-2,4-trimethylpentanamide

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Technology Process of (+)-[2S-(2R*,3S*,4S*)]-5-hydroxy-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N-2,4-trimethylpentanamide

There total 4 articles about (+)-[2S-(2R*,3S*,4S*)]-5-hydroxy-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N-2,4-trimethylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 151058-21-8
(+)-[2S-(2R*,3S*,4S*)]-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N-2,4-trimethylpentanamide

: 151058-22-9
(+)-[2S-(2R*,3S*,4S*)]-5-hydroxy-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N-2,4-trimethylpentanamide

Guidance literature:: With tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1021/jo00074a005

Reference yield: 56.0%

: 1253858-63-7
(-)-[2S-(2R*,3R*)]-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N,2,4-trimethyl-4-pentenamide

: 151058-22-9
(+)-[2S-(2R*,3S*,4S*)]-5-hydroxy-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N-2,4-trimethylpentanamide

Guidance literature:: (-)-[2S-(2R*,3R*)]-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N,2,4-trimethyl-4-pentenamide; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 0.75h;
DOI:10.1021/jo101598y

Reference yield:

: 151058-20-7
(2S,3R,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-pentanoic acid methoxy-methyl-amide

: 151058-22-9
(+)-[2S-(2R*,3S*,4S*)]-5-hydroxy-3-[(4-methoxyphenyl)methoxy]-N-methoxy-N-2,4-trimethylpentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaH / dimethylformamide

2: 86 percent / tetrabutylammonium fluoride trihydrate / dimethylformamide / 0 °C

With tetrabutyl ammonium fluoride; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jo00074a005