Benzeneethanamine, 2,3-diethoxy- (9CI)

Base Information

• Chemical Name: Benzeneethanamine, 2,3-diethoxy- (9CI)
• CAS No.: 408353-03-7
• Molecular Formula: C₁₂H₁₉NO₂
• Molecular Weight: 209.288
• Mol file: 408353-03-7.mol

Synonyms:Phenethylamine,2,3-diethoxy- (5CI)

Chemical Property of Benzeneethanamine, 2,3-diethoxy- (9CI)

Chemical Property:

• PSA: 44.48000
• LogP: 2.68550

Purity/Quality:

2,3-DIETHOXY-BENZENEETHANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneethanamine, 2,3-diethoxy- (9CI)

There total 4 articles about Benzeneethanamine, 2,3-diethoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-diethoxy-3-(2-nitro-vinyl)benzene (408353-28-6) → 2-(2,3-diethoxy-phenyl)ethylamine (408353-03-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 80 ℃; for 12h;

DOI:10.1021/jm3014103

Reference yield:

3-ethoxysalicylaldehyde (492-88-6) → 2-(2,3-diethoxy-phenyl)ethylamine (408353-03-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 6 h / 40 °C

2: ammonium acetate; acetic acid / 12 h / 100 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C

With lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; acetic acid; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1021/jm3014103

Reference yield:

2,3-diethoxy-benzaldehyde (24454-82-8) → 2-(2,3-diethoxy-phenyl)ethylamine (408353-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate; acetic acid / 12 h / 100 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C

With lithium aluminium tetrahydride; ammonium acetate; acetic acid; In tetrahydrofuran;

DOI:10.1021/jm3014103

upstream raw materials:

3-ethoxysalicylaldehyde

2,3-diethoxy-benzaldehyde

1,2-diethoxy-3-(2-nitro-vinyl)benzene

Downstream raw materials:

phenyl-acetic acid-(2,3-diethoxy-phenethylamide)

5,6-diethoxy-1-(2,3-diethoxy-phenyl)-3,4-dihydro-isoquinoline

(5,6-dimethoxy-3,4-dihydro-[1]isoquinolyl)-(3,4-dimethoxy-phenyl)-ketone

5,6-diethoxy-1-benzyl-3,4-dihydro-isoquinoline

Refernces