2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-phenyl-4,5-dihydro-1,3-oxazole

Base Information

Chemical Name:2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-phenyl-4,5-dihydro-1,3-oxazole
CAS No.:1085452-07-8
Molecular Formula:C₂₁H₂₁N₃O
Molecular Weight:331.417
Hs Code.:

Synonyms:2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-phenyl-4,5-dihydro-1,3-oxazole

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Chemical Property of 2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-phenyl-4,5-dihydro-1,3-oxazole

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Technology Process of 2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-phenyl-4,5-dihydro-1,3-oxazole

There total 6 articles about 2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-phenyl-4,5-dihydro-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1085454-08-5
N-[(1R)-2-hydroxy-1-phenylethyl]-5-methyl-1-(4-methyl-benzyl)-1H-pyrazole-3-carboxamide

: 1085452-07-8
2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-phenyl-4,5-dihydro-1,3-oxazole

Guidance literature:: With Burgess Reagent; In tetrahydrofuran; at 70 ℃; for 1h;

Reference yield:

: 1085453-43-5
tert-butyl 2-isopropylidene-1-(4-methylbenzyl)hydrazine-carboxylate

: 1085452-07-8
2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-phenyl-4,5-dihydro-1,3-oxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; water / tetrahydrofuran / 3 h / Heating / reflux

2.1: acetic acid / 4 h / 90 °C

3.1: sodium hydroxide; water / ethanol / 16 h / 70 °C

4.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 16 h / 20 °C

5.1: Burgess Reagent / tetrahydrofuran / 1 h / 70 °C

With hydrogenchloride; sodium hydroxide; Burgess Reagent; water; acetic acid; HATU; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1085453-45-7
methyl 5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxylate

: 1085452-07-8
2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-phenyl-4,5-dihydro-1,3-oxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / ethanol / 16 h / 70 °C

2.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 16 h / 20 °C

3.1: Burgess Reagent / tetrahydrofuran / 1 h / 70 °C

With sodium hydroxide; Burgess Reagent; water; HATU; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;