3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-trifluoromethylbenzoic acid

Base Information

Chemical Name:3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-trifluoromethylbenzoic acid
CAS No.:632624-79-4
Molecular Formula:C₂₇H₂₁F₄NO₃
Molecular Weight:483.462
Hs Code.:

Synonyms:3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-trifluoromethylbenzoic acid

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Chemical Property of 3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-trifluoromethylbenzoic acid

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Technology Process of 3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-trifluoromethylbenzoic acid

There total 5 articles about 3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-trifluoromethylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-trifluoromethylbenzoic acid methyl ester

: 632624-79-4
3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-trifluoromethylbenzoic acid

Guidance literature:: With sodium hydroxide; water; In ethanol; at 120 ℃; for 0.05h; Microwave irradiation;

Reference yield:

: 632627-75-9
5-methyl-2-(4-fluorobenzyloxy)benzaldehyde

: 632624-79-4
3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-trifluoromethylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 5 h / Heating / reflux

2: toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 0.17 h / 150 °C / Microwave irradiation

3: sodium hydroxide; water / ethanol / 0.05 h / 120 °C / Microwave irradiation

With sodium hydroxide; water; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; ethanol;

Reference yield:

: 613-84-3
2-hydroxy-5-methylbenzaldehyde

: 632624-79-4
3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-trifluoromethylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 1.75 h / Heating / reflux

2: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 5 h / Heating / reflux

3: toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 0.17 h / 150 °C / Microwave irradiation

4: sodium hydroxide; water / ethanol / 0.05 h / 120 °C / Microwave irradiation

With sodium hydroxide; water; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; ethanol; acetone;