(2S)-1-O-(1'-ethoxyethyl)-2-O-(p-methoxybenzyl)-3-O-(p-toluenesulfonyl)glycerol

Base Information

Chemical Name:(2S)-1-O-(1'-ethoxyethyl)-2-O-(p-methoxybenzyl)-3-O-(p-toluenesulfonyl)glycerol
CAS No.:301298-58-8
Molecular Formula:C₂₂H₃₀O₇S
Molecular Weight:438.542
Hs Code.:

Synonyms:(2S)-1-O-(1'-ethoxyethyl)-2-O-(p-methoxybenzyl)-3-O-(p-toluenesulfonyl)glycerol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-1-O-(1'-ethoxyethyl)-2-O-(p-methoxybenzyl)-3-O-(p-toluenesulfonyl)glycerol

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Technology Process of (2S)-1-O-(1'-ethoxyethyl)-2-O-(p-methoxybenzyl)-3-O-(p-toluenesulfonyl)glycerol

There total 5 articles about (2S)-1-O-(1'-ethoxyethyl)-2-O-(p-methoxybenzyl)-3-O-(p-toluenesulfonyl)glycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 109-92-2,25104-37-4
ethyl vinyl ether

: 301298-52-2
(2S)-2-O-(p-methoxybenzyl)-3-O-(p-toluenesulfonyl)glycerol

: 301298-58-8
(2S)-1-O-(1'-ethoxyethyl)-2-O-(p-methoxybenzyl)-3-O-(p-toluenesulfonyl)glycerol

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 48h;
DOI:10.1016/S0040-4020(00)00405-1

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 301298-58-8
(2S)-1-O-(1'-ethoxyethyl)-2-O-(p-methoxybenzyl)-3-O-(p-toluenesulfonyl)glycerol

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: 85 percent / dimethylformamide / 1.5 h / 20 °C

2.1: 40 percent / aq. Bu₄NHSO₄ / methanol / 8 h / 60 °C

3.1: 90 percent / pyridine / 0 - 20 °C

4.1: aq. NaIO₄ / methanol / 0.17 h / 0 °C

4.2: 75 percent / NaBH₄ / methanol / 2 h / 0 °C

5.1: 97 percent / CF₃COOH / 48 h / 20 °C

With pyridine; sodium periodate; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; trifluoroacetic acid; In methanol; N,N-dimethyl-formamide; 1.1: deprotonation / 1.2: Substitution / 2.1: Hydrolysis / 3.1: Tosylation / 4.1: Oxidation / 4.2: Reduction / 5.1: Addition;
DOI:10.1016/S0040-4020(00)00405-1

Reference yield:

: 301298-48-6
2,5-di-O-(p-methoxybenzyl)-D-mannitol

: 301298-58-8
(2S)-1-O-(1'-ethoxyethyl)-2-O-(p-methoxybenzyl)-3-O-(p-toluenesulfonyl)glycerol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / pyridine / 0 - 20 °C

2.1: aq. NaIO₄ / methanol / 0.17 h / 0 °C

2.2: 75 percent / NaBH₄ / methanol / 2 h / 0 °C

3.1: 97 percent / CF₃COOH / 48 h / 20 °C

With pyridine; sodium periodate; trifluoroacetic acid; In methanol; 1.1: Tosylation / 2.1: Oxidation / 2.2: Reduction / 3.1: Addition;
DOI:10.1016/S0040-4020(00)00405-1