diethyl 2-(methylthio)-1-<3-(4-nitrophenyl)propyl>imidazole-4,5-dicarboxylate

Base Information

Chemical Name:diethyl 2-(methylthio)-1-<3-(4-nitrophenyl)propyl>imidazole-4,5-dicarboxylate
CAS No.:218629-00-6
Molecular Formula:C₁₉H₂₃N₃O₆S
Molecular Weight:421.474
Hs Code.:

Synonyms:diethyl 2-(methylthio)-1-<3-(4-nitrophenyl)propyl>imidazole-4,5-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2-(methylthio)-1-<3-(4-nitrophenyl)propyl>imidazole-4,5-dicarboxylate

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Technology Process of diethyl 2-(methylthio)-1-<3-(4-nitrophenyl)propyl>imidazole-4,5-dicarboxylate

There total 1 articles about diethyl 2-(methylthio)-1-<3-(4-nitrophenyl)propyl>imidazole-4,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 53712-77-9
1-bromo-3-(4-nitrophenyl)propane

: 117121-00-3
diethyl 2-methylthio-4,5-imidazoledicarboxylate

: 218629-00-6
diethyl 2-(methylthio)-1-<3-(4-nitrophenyl)propyl>imidazole-4,5-dicarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 2.5h;
DOI:10.1021/jm9803119

Reference yield:

: 218629-00-6
diethyl 2-(methylthio)-1-<3-(4-nitrophenyl)propyl>imidazole-4,5-dicarboxylate

: 218629-06-2
(3-{3-[4-(acridin-9-ylamino)-phenyl]-propyl}-5-hydroxymethyl-2-methylsulfanyl-3H-imidazol-4-yl)-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / H₂ / Pt/C / methanol / 2 h / 2585.74 Torr

2: 60 percent / 12N aq. HCl / methanol / a) 20 deg C, 1 h, b) reflux, 30 min

3: 82 percent / LiAlH₄ / tetrahydrofuran / 2 h / 10 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; platinum on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm9803119

Reference yield:

: 218629-00-6
diethyl 2-(methylthio)-1-<3-(4-nitrophenyl)propyl>imidazole-4,5-dicarboxylate

: diethyl 1-<3-<4-(9-acridinylamino)phenyl>propyl>-2-(methylthio)imidazole-4,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / Pt/C / methanol / 2 h / 2585.74 Torr

2: 60 percent / 12N aq. HCl / methanol / a) 20 deg C, 1 h, b) reflux, 30 min

With hydrogenchloride; hydrogen; platinum on activated charcoal; In methanol;
DOI:10.1021/jm9803119