tert-butyl[((1R,2R)-4-[(3,4-dimethoxybenzyl)oxy]-1-{(1R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-2-methylbutyl)oxy]dimethylsilane

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Chemical Name:tert-butyl[((1R,2R)-4-[(3,4-dimethoxybenzyl)oxy]-1-{(1R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-2-methylbutyl)oxy]dimethylsilane
CAS No.:930285-64-6
Molecular Formula:C₂₇H₄₈O₆Si
Molecular Weight:496.76
Hs Code.:

Synonyms:tert-butyl[((1R,2R)-4-[(3,4-dimethoxybenzyl)oxy]-1-{(1R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-2-methylbutyl)oxy]dimethylsilane

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Chemical Property of tert-butyl[((1R,2R)-4-[(3,4-dimethoxybenzyl)oxy]-1-{(1R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-2-methylbutyl)oxy]dimethylsilane

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Technology Process of tert-butyl[((1R,2R)-4-[(3,4-dimethoxybenzyl)oxy]-1-{(1R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-2-methylbutyl)oxy]dimethylsilane

There total 7 articles about tert-butyl[((1R,2R)-4-[(3,4-dimethoxybenzyl)oxy]-1-{(1R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-2-methylbutyl)oxy]dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 930285-63-5
(3R,4R,5R)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methylhexan-1-ol

: 905589-59-5
(3,4-dimethoxoxyphenyl)methyl 2,2,2-trichloroacetimidate

: 930285-64-6
tert-butyl[((1R,2R)-4-[(3,4-dimethoxybenzyl)oxy]-1-{(1R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-2-methylbutyl)oxy]dimethylsilane

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 72h;
DOI:10.1021/ol0629317

Reference yield:

: 71565-21-4
(2S,4'R)-(+)-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-1-propanol

: 930285-64-6
tert-butyl[((1R,2R)-4-[(3,4-dimethoxybenzyl)oxy]-1-{(1R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-2-methylbutyl)oxy]dimethylsilane

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / 4.5 h / -78 - 20 °C

2: diethylzinc / Pd(OAc)2; PPh₃ / tetrahydrofuran; hexane / 72 h / -20 °C

3: 95 percent / 2,6-lutidine / CH₂Cl₂ / -50 - 20 °C

4: 1,2-dimethoxy-ethane / 3.08 h / 0 - 20 °C

5: 3.11 g / H₂O₂; NaOH / 1,2-dimethoxy-ethane; H₂O / 0.42 h / 0 - 20 °C

6: 95 percent / sodium borohydride / tetrahydrofuran; methanol / 1 h / 0 °C

7: 97 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 72 h

With 2,6-dimethylpyridine; sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; dihydrogen peroxide; diethylzinc; pyridinium p-toluenesulfonate; dimethyl sulfoxide; triethylamine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; dichloromethane; water; 1: Swern oxidation / 2: Marshall reaction;
DOI:10.1021/ol0629317

Reference yield:

: 77398-87-9
(2R)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propanal

: 930285-64-6
tert-butyl[((1R,2R)-4-[(3,4-dimethoxybenzyl)oxy]-1-{(1R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-2-methylbutyl)oxy]dimethylsilane

Guidance literature:: Multi-step reaction with 6 steps

1: diethylzinc / Pd(OAc)2; PPh₃ / tetrahydrofuran; hexane / 72 h / -20 °C

2: 95 percent / 2,6-lutidine / CH₂Cl₂ / -50 - 20 °C

3: 1,2-dimethoxy-ethane / 3.08 h / 0 - 20 °C

4: 3.11 g / H₂O₂; NaOH / 1,2-dimethoxy-ethane; H₂O / 0.42 h / 0 - 20 °C

5: 95 percent / sodium borohydride / tetrahydrofuran; methanol / 1 h / 0 °C

6: 97 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 72 h

With 2,6-dimethylpyridine; sodium hydroxide; sodium tetrahydroborate; dihydrogen peroxide; diethylzinc; pyridinium p-toluenesulfonate; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; dichloromethane; water; 1: Marshall reaction;
DOI:10.1021/ol0629317