(R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]quinolin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Base Information

Chemical Name:(R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]quinolin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
CAS No.:1353547-29-1
Molecular Formula:C₃₂H₃₄F₃NO₄Si
Molecular Weight:581.707
Hs Code.:

Synonyms:(R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]quinolin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Chemical Property of (R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]quinolin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Technology Process of (R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]quinolin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

There total 7 articles about (R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]quinolin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1353547-23-5
(R)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]quinolin-4(1H)-one

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 1353547-29-1
(R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]quinolin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 16h; optical yield given as %de; Inert atmosphere;
DOI:10.1055/s-0030-1260198

Reference yield:

: 1353547-16-6
(R)-N-(2-acetylphenyl)-2-(tert-butyldimethylsiloxy)-2-phenylacetamide

: 1353547-29-1
(R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]quinolin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl trifluoromethanesulfonate; triethylamine / 1,2-dichloro-ethane / 32 h / 95 °C / Inert atmosphere

2: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

With pyridine; trimethylsilyl trifluoromethanesulfonate; triethylamine; In dichloromethane; 1,2-dichloro-ethane; 1: Camps cyclization;
DOI:10.1055/s-0030-1260198

Reference yield:

: 119619-48-6
(R)-<(tert-butyldimethylsilyl)oxy>phenylacetic acid

: 1353547-29-1
(R)-2-[(R)-(tert-butyldimethylsiloxy)(phenyl)methyl]quinolin-4-yl 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C

2: triethylamine / dichloromethane; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3: trimethylsilyl trifluoromethanesulfonate; triethylamine / 1,2-dichloro-ethane / 32 h / 95 °C / Inert atmosphere

4: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

With pyridine; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 3: Camps cyclization;
DOI:10.1055/s-0030-1260198