6β-(N-benzyl)methylamino-17-(cyclopropylmethyl)-4,5α-epoxy-3,14β-dihydroxymorphinan-10-one

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Chemical Name:6β-(N-benzyl)methylamino-17-(cyclopropylmethyl)-4,5α-epoxy-3,14β-dihydroxymorphinan-10-one
CAS No.:1054312-64-9
Molecular Formula:C₂₈H₃₂N₂O₄
Molecular Weight:460.573
Hs Code.:

Synonyms:6β-(N-benzyl)methylamino-17-(cyclopropylmethyl)-4,5α-epoxy-3,14β-dihydroxymorphinan-10-one

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Chemical Property of 6β-(N-benzyl)methylamino-17-(cyclopropylmethyl)-4,5α-epoxy-3,14β-dihydroxymorphinan-10-one

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Technology Process of 6β-(N-benzyl)methylamino-17-(cyclopropylmethyl)-4,5α-epoxy-3,14β-dihydroxymorphinan-10-one

There total 4 articles about 6β-(N-benzyl)methylamino-17-(cyclopropylmethyl)-4,5α-epoxy-3,14β-dihydroxymorphinan-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1054312-88-7
6β-(N-benzyl)methylamino-17-(cyclopropylmethyl)-4,5α-epoxy-14β-hydroxy-3-methoxymorphinan-10-one

: 1054312-64-9
6β-(N-benzyl)methylamino-17-(cyclopropylmethyl)-4,5α-epoxy-3,14β-dihydroxymorphinan-10-one

Guidance literature:: With sodium 1-propanethiolate; In N,N-dimethyl-formamide; at 95 ℃; for 3h;
DOI:10.1248/cpb.52.664

Reference yield:

: 96445-13-5
17-(cyclopropylmethyl)-4,5α-epoxy-14β-hydroxy-3-methoxymorphinan-6,10-dione

: 1054312-64-9
6β-(N-benzyl)methylamino-17-(cyclopropylmethyl)-4,5α-epoxy-3,14β-dihydroxymorphinan-10-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: PhCO₂H / benzene / 16 h / Heating

1.2: 66 percent / NaBH₃CN / methanol / 1.67 h / 0 - 20 °C

2.1: 91 percent / n-PrSNa / dimethylformamide / 3 h / 95 °C

With benzoic acid; sodium 1-propanethiolate; In N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.52.664

Reference yield:

: 691409-41-3
C₂₄H₂₉NO₈

: 1054312-64-9
6β-(N-benzyl)methylamino-17-(cyclopropylmethyl)-4,5α-epoxy-3,14β-dihydroxymorphinan-10-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 44.76 g / aq. HCl / dioxane / 21 h / Heating

2.1: 41.14 g / KI; K₂CO₃ / dimethylformamide / 3.5 h / 20 °C

3.1: PhCO₂H / benzene / 16 h / Heating

3.2: 66 percent / NaBH₃CN / methanol / 1.67 h / 0 - 20 °C

4.1: 91 percent / n-PrSNa / dimethylformamide / 3 h / 95 °C

With hydrogenchloride; potassium carbonate; benzoic acid; potassium iodide; sodium 1-propanethiolate; In 1,4-dioxane; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.52.664