N-[5-chloro-6-(2,4-dichlorophenyl)-7-isopropylaminopyrazolo[1,5-a]pyrimidine-3-carbonyl]methanesulphonamide

Base Information

Chemical Name:N-[5-chloro-6-(2,4-dichlorophenyl)-7-isopropylaminopyrazolo[1,5-a]pyrimidine-3-carbonyl]methanesulphonamide
CAS No.:907180-31-8
Molecular Formula:C₁₇H₁₆Cl₃N₅O₃S
Molecular Weight:476.771
Hs Code.:

Synonyms:N-[5-chloro-6-(2,4-dichlorophenyl)-7-isopropylaminopyrazolo[1,5-a]pyrimidine-3-carbonyl]methanesulphonamide

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Chemical Property of N-[5-chloro-6-(2,4-dichlorophenyl)-7-isopropylaminopyrazolo[1,5-a]pyrimidine-3-carbonyl]methanesulphonamide

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Technology Process of N-[5-chloro-6-(2,4-dichlorophenyl)-7-isopropylaminopyrazolo[1,5-a]pyrimidine-3-carbonyl]methanesulphonamide

There total 5 articles about N-[5-chloro-6-(2,4-dichlorophenyl)-7-isopropylaminopyrazolo[1,5-a]pyrimidine-3-carbonyl]methanesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 863431-02-1
5-chloro-6-(2,4-dichlorophenyl)-7-isopropylaminopyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 3144-09-0
methanesulfonamide

: 907180-31-8
N-[5-chloro-6-(2,4-dichlorophenyl)-7-isopropylaminopyrazolo[1,5-a]pyrimidine-3-carbonyl]methanesulphonamide

Guidance literature:: 5-chloro-6-(2,4-dichlorophenyl)-7-isopropylaminopyrazolo[1,5-a]pyrimidine-3-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

methanesulfonamide; With pyridine; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 907180-94-3
methyl 6-(2,4-dichlorophenyl)-5,7-dihydroxypyrazolo[1,5-a]pyrimidine-3-carboxylate

: 907180-31-8
N-[5-chloro-6-(2,4-dichlorophenyl)-7-isopropylaminopyrazolo[1,5-a]pyrimidine-3-carbonyl]methanesulphonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 120 °C

1.2: 120 °C

2.1: potassium carbonate / acetonitrile / 20 °C / Cooling with ice

3.1: potassium hydroxide; water / 1,4-dioxane / 15 h / 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane

4.2: 20 °C

With oxalyl dichloride; water; potassium carbonate; potassium hydroxide; trichlorophosphate; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 138485-31-1
dimethyl 2-(2,4-dichlorophenyl)malonate

: 907180-31-8
N-[5-chloro-6-(2,4-dichlorophenyl)-7-isopropylaminopyrazolo[1,5-a]pyrimidine-3-carbonyl]methanesulphonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tributyl-amine / 3 h / 185 °C

2.1: trichlorophosphate / 120 °C

2.2: 120 °C

3.1: potassium carbonate / acetonitrile / 20 °C / Cooling with ice

4.1: potassium hydroxide; water / 1,4-dioxane / 15 h / 20 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane

5.2: 20 °C

With oxalyl dichloride; tributyl-amine; water; potassium carbonate; potassium hydroxide; trichlorophosphate; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; acetonitrile;