7,16-Dimethyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

Base Information

• Chemical Name: 7,16-Dimethyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane
• CAS No.: 31255-13-7
• Molecular Formula: C₁₄H₃₀N₂O₄
• Molecular Weight: 290.403
• DSSTox Substance ID: DTXSID801192731
• Nikkaji Number: J1.158.052A
• Mol file: 31255-13-7.mol

Synonyms:7,16-dimethyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane;31255-13-7;1,4,10,13-Tetraoxa-7,16-diazacyclooctadecane, 7,16-dimethyl-;Oprea1_439056;SCHEMBL11337084;DTXSID801192731;STL357211;AKOS021983234;1,10-Dimethyl-1,10-diaza-18-crown-6;SR-01000389999;SR-01000389999-1;1,10-dimethyl-4,7,13,16-tetraoxa-1,10-diazacyclooctadecan

Chemical Property of 7,16-Dimethyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

Chemical Property:

• XLogP3: -0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 290.22055744
• Heavy Atom Count: 20
• Complexity: 177

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1CCOCCOCCN(CCOCCOCC1)C

Technology Process of 7,16-Dimethyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

There total 2 articles about 7,16-Dimethyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-bis-(2-dimethylamino-ethoxy)-ethane (3065-46-1) → 7,16-dimethyl-7,16-diaza-1,4,10,13-tetraoxacyclooctadecane (31255-13-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / acetonitrile / 20 h / 25 °C / 8250660 Torr

2: 59 percent / triphenylphosphine / dimethylformamide / Heating

With triphenylphosphine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/c39890000184

Reference yield:

triethylene glycol di-(p-toluenesulfonate) (19249-03-7) → 7,16-dimethyl-7,16-diaza-1,4,10,13-tetraoxacyclooctadecane (31255-13-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / K₂CO₃, tetrabutylammonium chloride / dimethylformamide / 12 h / 80 °C

2: 1.) Li, NH₃

With tetrabutyl-ammonium chloride; ammonia; lithium; potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

7,16-dimethyl-7,16-diaza-1,4,10,13-tetraoxacyclooctadecane (31255-13-7) → [2.2.2]cryptande (23978-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / acetone / 20 h / 25 °C / 7500600 Torr

2: 65 percent / triphenylphosphine / dimethylformamide / 5 h / Heating

With triphenylphosphine; In N,N-dimethyl-formamide; acetone;

upstream raw materials:

1,2-bis-(2-dimethylamino-ethoxy)-ethane

triethylene glycol di-(p-toluenesulfonate)

Downstream raw materials:

kryptofix 221

[2.2.2]cryptande