6-Phenyl-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid amide

Base Information

• Chemical Name: 6-Phenyl-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid amide
• CAS No.: 122384-72-9
• Molecular Formula: C₁₈H₁₄N₄O
• Molecular Weight: 302.335
• Mol file: 122384-72-9.mol

Synonyms:6-Phenyl-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid amide

Chemical Property of 6-Phenyl-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Phenyl-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid amide

There total 3 articles about 6-Phenyl-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Phenyl-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester (117047-24-2) → 6-Phenyl-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid amide (122384-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 2 N NaOH / ethanol / 0.5 h / Heating

2: 1) ethyl chloroformate, Et₃N, 2) NH₃ gas / 1) CH₂Cl₂, 15 to 20 deg C, 1 h

With sodium hydroxide; ammonia; chloroformic acid ethyl ester; triethylamine; In ethanol;

DOI:10.1021/jm00130a010

Reference yield:

2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one (2898-08-0) → 6-Phenyl-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid amide (122384-72-9)

Guidance literature:

Multi-step reaction with 3 steps

2: 95 percent / 2 N NaOH / ethanol / 0.5 h / Heating

3: 1) ethyl chloroformate, Et₃N, 2) NH₃ gas / 1) CH₂Cl₂, 15 to 20 deg C, 1 h

With sodium hydroxide; ammonia; chloroformic acid ethyl ester; triethylamine; In ethanol;

DOI:10.1021/jm00130a010

Reference yield:

6-phenyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid (122384-71-8) → 6-Phenyl-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid amide (122384-72-9)

Guidance literature:

With ammonia; chloroformic acid ethyl ester; triethylamine; Yield given. Multistep reaction; 1) CH₂Cl₂, 15 to 20 deg C, 1 h;

DOI:10.1021/jm00130a010

upstream raw materials:

6-phenyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid

6-Phenyl-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester

2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one

Downstream raw materials:

6-phenyl-4H-imidazo<1,5-a><1,4>benzpdiazepine-3-carbonitrile