2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-(2,3,4-tetra-O-acetyl-β-D-xylopyranosyl)-oxymethyluridine

Base Information

Chemical Name:2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-(2,3,4-tetra-O-acetyl-β-D-xylopyranosyl)-oxymethyluridine
CAS No.:942271-22-9
Molecular Formula:C₄₂H₄₆N₂O₁₅
Molecular Weight:818.832
Hs Code.:

Synonyms:2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-(2,3,4-tetra-O-acetyl-β-D-xylopyranosyl)-oxymethyluridine

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Chemical Property of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-(2,3,4-tetra-O-acetyl-β-D-xylopyranosyl)-oxymethyluridine

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Technology Process of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-(2,3,4-tetra-O-acetyl-β-D-xylopyranosyl)-oxymethyluridine

There total 9 articles about 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-(2,3,4-tetra-O-acetyl-β-D-xylopyranosyl)-oxymethyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 942271-10-5
2'-deoxy-5-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)oxymethyluridine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 942271-22-9
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-(2,3,4-tetra-O-acetyl-β-D-xylopyranosyl)-oxymethyluridine

Guidance literature:: With pyridine; at 20 ℃; for 4h;
DOI:10.1002/anie.200604635

Reference yield:

: 942270-83-9
3',5'-bis(O-tert-butyldimethylsilyl)-2'-deoxy-5-(2,3,4-tris-O-benzoyl-β-D-4-xylopyranosyl)oxymethyluridine

: 942271-22-9
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-(2,3,4-tetra-O-acetyl-β-D-xylopyranosyl)-oxymethyluridine

Guidance literature:: Multi-step reaction with 4 steps

1: NaOMe; methanol / 12 h

2: 0.196 g / pyridine / 6 h / 20 °C

3: 85 percent / Et₃N*3HF; pyridine / tetrahydrofuran / 16 h / 20 °C

4: 78 percent / pyridine / 4 h / 20 °C

With pyridine; methanol; sodium methylate; triethylamine tris(hydrogen fluoride); In tetrahydrofuran;
DOI:10.1002/anie.200604635

Reference yield:

: C₂₇H₅₀N₂O₁₀Si₂

: 942271-22-9
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-(2,3,4-tetra-O-acetyl-β-D-xylopyranosyl)-oxymethyluridine

Guidance literature:: Multi-step reaction with 3 steps

1: 0.196 g / pyridine / 6 h / 20 °C

2: 85 percent / Et₃N*3HF; pyridine / tetrahydrofuran / 16 h / 20 °C

3: 78 percent / pyridine / 4 h / 20 °C

With pyridine; triethylamine tris(hydrogen fluoride); In tetrahydrofuran;
DOI:10.1002/anie.200604635