(R)-3-phenyl-2-N-methyl-2-N-diphenylphosphinamino-1-diphenylphosphinoxypropane

Base Information

• Chemical Name: (R)-3-phenyl-2-N-methyl-2-N-diphenylphosphinamino-1-diphenylphosphinoxypropane
• CAS No.: 102249-19-4
• Molecular Formula: C₃₄H₃₃NOP₂
• Molecular Weight: 533.59
• Mol file: 102249-19-4.mol

Synonyms:(R)-3-phenyl-2-N-methyl-2-N-diphenylphosphinamino-1-diphenylphosphinoxypropane

Chemical Property of (R)-3-phenyl-2-N-methyl-2-N-diphenylphosphinamino-1-diphenylphosphinoxypropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-phenyl-2-N-methyl-2-N-diphenylphosphinamino-1-diphenylphosphinoxypropane

There total 3 articles about (R)-3-phenyl-2-N-methyl-2-N-diphenylphosphinamino-1-diphenylphosphinoxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

chloro-diphenylphosphine (1079-66-9,74391-44-9) + (2R)-2-(Methylamino)-3-phenylpropan-1-ol (102339-81-1) → (R)-3-phenyl-2-N-methyl-2-N-diphenylphosphinamino-1-diphenylphosphinoxypropane (102249-19-4)

Guidance literature:

With triethylamine; In benzene; at 40 - 50 ℃; for 3h;

DOI:10.1007/BF00955816

Reference yield:

(-)-(R)-N-formylphenylalanine (59366-89-1) → (R)-3-phenyl-2-N-methyl-2-N-diphenylphosphinamino-1-diphenylphosphinoxypropane (102249-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄

2: Et₃N / benzene

With lithium aluminium tetrahydride; triethylamine; In benzene;

Reference yield:

D-(R)-phenylalanine (673-06-3,25191-15-5,658-69-5,67675-33-6) → (R)-3-phenyl-2-N-methyl-2-N-diphenylphosphinamino-1-diphenylphosphinoxypropane (102249-19-4)

Guidance literature:

Multi-step reaction with 3 steps

1: Ac₂O

2: LiAlH₄ / tetrahydrofuran

3: 86 percent / triethylamine / benzene / 3 h / 40 - 50 °C

With lithium aluminium tetrahydride; acetic anhydride; triethylamine; In tetrahydrofuran; benzene;

DOI:10.1007/BF00955816

upstream raw materials:

chloro-diphenylphosphine

(2R)-2-(Methylamino)-3-phenylpropan-1-ol

(-)-(R)-N-formylphenylalanine

D-(R)-phenylalanine