Technology Process of 2-(formylmethyl)-2,3,4,5,6,7-hexahydro-1,5-methano-3-oxo-7-<(p-methoxyphenyl)sulfonyl>-1H-azocino<4,3-b>indole
There total 11 articles about 2-(formylmethyl)-2,3,4,5,6,7-hexahydro-1,5-methano-3-oxo-7-<(p-methoxyphenyl)sulfonyl>-1H-azocino<4,3-b>indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(dimethylthio)sulfonium tetrafluoroborate;
In
dichloromethane;
at 21 ℃;
for 48h;
DOI:10.1021/jo00027a016
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 73 percent / aq. acetic acid / 10 h / Heating
2: 99.6 percent / concd HCl, dimethoxypropane / 2 h / 20 °C
3: 85 percent / dichlorodicyanoquinone / tetrahydrofuran; H2O / 2 h / 0 °C
4: tetra-N-benzylammonium chloride, 30percent NaOH / CH2Cl2 / 1 h
5: aq. lithium hydroxide / tetrahydrofuran / 1 h / 23 °C
6: 1.) triethylamine / 1.) methylene dichloride, 0 deg C, 2 h 2.) methylene dichloride, 25 deg C, 12 h
7: 100 percent / sodium borohydride / methanol / 1 h / 21 °C
8: 98 percent / trifluoroacetic acid / CH2Cl2 / 12 h / 0 °C
9: 1.) boron trifluoride etherate / 1.) tetrahydrofuran, 21 deg C, 15 min 2.) 21 deg C, 3 h
10: 100 percent / (dimethylthio)sulfonium tetrafluoroborate / CH2Cl2 / 48 h / 21 °C
With
hydrogenchloride; lithium hydroxide; sodium hydroxide; sodium tetrahydroborate; Bn4NCl; dimethoxypropane; (dimethylthio)sulfonium tetrafluoroborate; boron trifluoride diethyl etherate; acetic acid; triethylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo00027a016
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 73 percent / aq. acetic acid / 10 h / Heating
2: 99.6 percent / concd HCl, dimethoxypropane / 2 h / 20 °C
3: 85 percent / dichlorodicyanoquinone / tetrahydrofuran; H2O / 2 h / 0 °C
4: tetra-N-benzylammonium chloride, 30percent NaOH / CH2Cl2 / 1 h
5: aq. lithium hydroxide / tetrahydrofuran / 1 h / 23 °C
6: 1.) triethylamine / 1.) methylene dichloride, 0 deg C, 2 h 2.) methylene dichloride, 25 deg C, 12 h
7: 100 percent / sodium borohydride / methanol / 1 h / 21 °C
8: 98 percent / trifluoroacetic acid / CH2Cl2 / 12 h / 0 °C
9: 1.) boron trifluoride etherate / 1.) tetrahydrofuran, 21 deg C, 15 min 2.) 21 deg C, 3 h
10: 100 percent / (dimethylthio)sulfonium tetrafluoroborate / CH2Cl2 / 48 h / 21 °C
With
hydrogenchloride; lithium hydroxide; sodium hydroxide; sodium tetrahydroborate; Bn4NCl; dimethoxypropane; (dimethylthio)sulfonium tetrafluoroborate; boron trifluoride diethyl etherate; acetic acid; triethylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo00027a016
