(2R,3R)-benzoic acid 2-azido-3,3,3-trifluoro-1-hydroxymethylpropyl ester

Base Information

Chemical Name:(2R,3R)-benzoic acid 2-azido-3,3,3-trifluoro-1-hydroxymethylpropyl ester
CAS No.:746652-70-0
Molecular Formula:C₁₁H₁₀F₃N₃O₃
Molecular Weight:289.214
Hs Code.:

Synonyms:(2R,3R)-benzoic acid 2-azido-3,3,3-trifluoro-1-hydroxymethylpropyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-benzoic acid 2-azido-3,3,3-trifluoro-1-hydroxymethylpropyl ester

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Technology Process of (2R,3R)-benzoic acid 2-azido-3,3,3-trifluoro-1-hydroxymethylpropyl ester

There total 4 articles about (2R,3R)-benzoic acid 2-azido-3,3,3-trifluoro-1-hydroxymethylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 746652-69-7
(2R,3R)-benzoic acid 2-azido-1-benzyloxymethyl-3,3,3-trifluoropropyl ester

: 746652-70-0
(2R,3R)-benzoic acid 2-azido-3,3,3-trifluoro-1-hydroxymethylpropyl ester

Guidance literature:: With boron trichloride; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1021/jo0497611

Reference yield:

: 1863-63-4,21292-26-2,28271-83-2,143502-10-7
ammonium benzoate

: 746652-70-0
(2R,3R)-benzoic acid 2-azido-3,3,3-trifluoro-1-hydroxymethylpropyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylformamide / 4 h / 80 °C

1.2: 97 percent / H₂SO₄ / tetrahydrofuran; H₂O / 20 °C

2.1: 88 percent / pyridine / 1 h / -40 °C

3.1: 96 percent / NaN₃ / dimethylsulfoxide / 6 h / 40 °C

4.1: 98 percent / BCl₃ / CH₂Cl₂ / 2 h / -78 °C

With pyridine; sodium azide; boron trichloride; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo0497611

Reference yield:

: 746652-58-4
(2S,3S)-benzoic acid 1-benzyloxymethyl-3,3,3-trifluoro-2-hydroxypropyl ester

: 746652-70-0
(2R,3R)-benzoic acid 2-azido-3,3,3-trifluoro-1-hydroxymethylpropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / pyridine / 1 h / -40 °C

2: 96 percent / NaN₃ / dimethylsulfoxide / 6 h / 40 °C

3: 98 percent / BCl₃ / CH₂Cl₂ / 2 h / -78 °C

With pyridine; sodium azide; boron trichloride; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo0497611