(2R,4S)-8-(benzyloxy)-4-hydroxy-2-methyloct-6-yn-1-yl 2,2-dimethylpropanoate

Base Information

Chemical Name:(2R,4S)-8-(benzyloxy)-4-hydroxy-2-methyloct-6-yn-1-yl 2,2-dimethylpropanoate
CAS No.:1472660-16-4
Molecular Formula:C₂₁H₃₀O₄
Molecular Weight:346.467
Hs Code.:

Synonyms:(2R,4S)-8-(benzyloxy)-4-hydroxy-2-methyloct-6-yn-1-yl 2,2-dimethylpropanoate

Suppliers and Price of (2R,4S)-8-(benzyloxy)-4-hydroxy-2-methyloct-6-yn-1-yl 2,2-dimethylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4S)-8-(benzyloxy)-4-hydroxy-2-methyloct-6-yn-1-yl 2,2-dimethylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4S)-8-(benzyloxy)-4-hydroxy-2-methyloct-6-yn-1-yl 2,2-dimethylpropanoate

There total 9 articles about (2R,4S)-8-(benzyloxy)-4-hydroxy-2-methyloct-6-yn-1-yl 2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 4039-82-1
Benzyl propargyl ether

: 1472660-14-2
(2R)-2-methyl-3-[(2S)-oxiran-2-yl]propyl 2,2-dimethylpropanoate

: 1472660-16-4
(2R,4S)-8-(benzyloxy)-4-hydroxy-2-methyloct-6-yn-1-yl 2,2-dimethylpropanoate

Guidance literature:: Benzyl propargyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

(2R)-2-methyl-3-[(2S)-oxiran-2-yl]propyl 2,2-dimethylpropanoate; With boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1002/hlca.201200519

Reference yield:

: (E)-(S)-3-(1,4-Dioxa-spiro[4.5]dec-2-yl)-acrylic acid ethyl ester

: 1472660-16-4
(2R,4S)-8-(benzyloxy)-4-hydroxy-2-methyloct-6-yn-1-yl 2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

2.1: water; lithium hydroxide / methanol; tetrahydrofuran / 10 h

3.1: triethylamine / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

4.1: lithium chloride / tetrahydrofuran / 5 h / -20 - 0 °C / Inert atmosphere

5.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: 3 h / -78 °C / Inert atmosphere

6.1: lithium borohydride / methanol; tetrahydrofuran; diethyl ether / 1 h / -10 °C / Inert atmosphere

7.1: pyridine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

8.1: Dowex 50WX₈ / methanol / 48 h / 20 °C / Inert atmosphere

9.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

9.2: 0.5 h / 0 - 20 °C / Inert atmosphere

10.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

10.2: 0.67 h / -78 °C / Inert atmosphere

With pyridine; dmap; sodium tetrahydroborate; lithium borohydride; n-butyllithium; nickel(II) chloride hexahydrate; water; sodium hexamethyldisilazane; sodium hydride; triethylamine; lithium chloride; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; mineral oil;
DOI:10.1002/hlca.201200519

Reference yield:

: C₁₆H₂₆O₅

: 1472660-16-4
(2R,4S)-8-(benzyloxy)-4-hydroxy-2-methyloct-6-yn-1-yl 2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium chloride / tetrahydrofuran / 5 h / -20 - 0 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C / Inert atmosphere

3.1: lithium borohydride / methanol; tetrahydrofuran; diethyl ether / 1 h / -10 °C / Inert atmosphere

4.1: pyridine; dmap / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5.1: Dowex 50WX₈ / methanol / 48 h / 20 °C / Inert atmosphere

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

6.2: 0.5 h / 0 - 20 °C / Inert atmosphere

7.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

7.2: 0.67 h / -78 °C / Inert atmosphere

With pyridine; dmap; lithium borohydride; n-butyllithium; sodium hexamethyldisilazane; sodium hydride; lithium chloride; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; mineral oil;
DOI:10.1002/hlca.201200519