(4-Chloro-2-iodophenyl)methanol

Base Information

• Chemical Name: (4-Chloro-2-iodophenyl)methanol
• CAS No.: 244104-55-0
• Molecular Formula: C₇H₆ClIO
• Molecular Weight: 268.482
• European Community (EC) Number: 817-975-0
• Mol file: 244104-55-0.mol

Synonyms:(4-CHLORO-2-IODOPHENYL)METHANOL;244104-55-0;4-CHLORO-2-IODOBENZYL ALCOHOL;SCHEMBL1197989;UDXMQUOKYIISFP-UHFFFAOYSA-N;MFCD11847259;AKOS027264844;CS-0378783;FT-0701747;C90809;EN300-187616;Z1269244634

Chemical Property of (4-Chloro-2-iodophenyl)methanol

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 267.91519
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

98% ^*data from raw suppliers

(4-chloro-2-iodophenyl)methanol 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)I)CO

Technology Process of (4-Chloro-2-iodophenyl)methanol

There total 4 articles about (4-Chloro-2-iodophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(4-chloro-2-iodobenzyloxy)tetrahydro-2H-pyran (1385840-30-1) → (4-chloro-2-iodophenyl)methanol (244104-55-0)

Guidance literature:

With zinc(II) trifluoromethanesulfonate; In methanol; at 20 ℃; for 0.583333h;

DOI:10.1134/S1070363213120384

Reference yield: 92.0%

→ (4-chloro-2-iodophenyl)methanol (244104-55-0)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 75.0%

4-chloro-2-iodobenzoic acid (13421-13-1) → (4-chloro-2-iodophenyl)methanol (244104-55-0)

Guidance literature:

4-chloro-2-iodobenzoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 1.5h;

With sodium tetrahydroborate; In tetrahydrofuran; for 2.5h;

upstream raw materials:

4-chloro-2-iodobenzoic acid

2-(4-chloro-2-iodobenzyloxy)tetrahydro-2H-pyran

2-Amino-4-chlorobenzoic acid

Downstream raw materials:

[4-chloro-2-({(3S)-4-[ (4-chlorophenyl)acetyl]-3-methylpiperazin-1-yl}methyl) phenyl]acetic acid

4-chloro-1-(chloromethyl)-2-iodobenzene

2-(4-chloro-2-iodophenyl)acetonitrile

2-(4-chloro-2-iodophenyl)acetic acid