5-Bromo-2-chloro-3-cyanopyridine

Base Information

• Chemical Name: 5-Bromo-2-chloro-3-cyanopyridine
• CAS No.: 405224-23-9
• Molecular Formula: C6H2BrClN2
• Molecular Weight: 217.452
• Hs Code.: 2933399090
• Mol file: 405224-23-9.mol

Synonyms:5-Bromo-2-chloro-3-cyanopyridine;5-Bromo-2-chloropyridine-3-carbonitrile;

Chemical Property of 5-Bromo-2-chloro-3-cyanopyridine

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Melting Point: 138.0 to 142.0 °C
• Refractive Index: 1.629
• Boiling Point: 272.677 °C at 760 mmHg
• PKA: -4.56±0.10(Predicted)
• Flash Point: 118.711 °C
• PSA: 36.68000
• Density: 1.854 g/cm³
• LogP: 2.36918
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-2-chloronicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-2-chloro-3-cyanopyridine is used as pharmaceutical intermediate.

Technology Process of 5-Bromo-2-chloro-3-cyanopyridine

There total 7 articles about 5-Bromo-2-chloro-3-cyanopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile (405224-22-8) → 5-bromo-2-chloropyridine-3-carbonitrile (405224-23-9)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; Heating;

DOI:10.1016/S0960-894X(03)00134-3

Reference yield: 88.0%

2-amino-5-bromonicotinonitrile (709652-82-4) → 5-bromo-2-chloropyridine-3-carbonitrile (405224-23-9)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at -5 - 20 ℃;

Reference yield: 85.0%

2-hydroxy-3-cyano-5-bromopyridine (405224-22-8) → 5-bromo-2-chloropyridine-3-carbonitrile (405224-23-9)

Guidance literature:

With trichlorophosphate; at 0 ℃; for 5h; Reflux;

DOI:10.1016/j.bmcl.2018.02.054

upstream raw materials:

5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile

pyrid-2-one-3-carbonitrile

2-amino-5-bromonicotinonitrile

2-hydroxy-3-cyano-5-bromopyridine

Downstream raw materials:

5-bromo-1H-pyrazolo[3,4-b]pyridine-3-amine

C₂₀H₂₄BrN₅O

5-bromo-1-[(4-methoxyphenyl)methyl]pyrazolo[3,4-b]pyridine-3-amine

(E)-3-(3-amino-1H-pyrazolo[3,4-b]pyridin-5-yl)-N-methyl-N-((1-methyl-1H-indol-2-yl)methyl)acrylamide

Refernces

• 1、 Jing, Liandong,Tang, Yanbo,Xiao, Zhiyan. "Discovery of novel CDK inhibitors via scaffold hopping from CAN508". supporting information. p. 1386 - 1391. Retrieved 2018/03/21.
• 2、 -. "HETEROCYCLIC COMPOUNDS AS INHIBITORS OF FATTY ACID BIOSYSNTHESIS FOR BACTERIAL INFECTIONS". Paragraph 0067; 0069. . Retrieved 2014/09/16.