(3R,4S)-3-<3-<3-(p-toluenesulfonyloxy)propyl>-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

Base Information

Chemical Name:(3R*,4S*)-3-<3-<3-(p-toluenesulfonyloxy)propyl>-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane
CAS No.:104946-84-1
Molecular Formula:C₃₈H₅₀O₇S
Molecular Weight:650.877
Hs Code.:

Synonyms:(3R*,4S*)-3-<3-<3-(p-toluenesulfonyloxy)propyl>-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R*,4S*)-3-<3-<3-(p-toluenesulfonyloxy)propyl>-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

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Technology Process of (3R*,4S*)-3-<3-<3-(p-toluenesulfonyloxy)propyl>-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

There total 1 articles about (3R*,4S*)-3-<3-<3-(p-toluenesulfonyloxy)propyl>-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 104946-83-0
3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propan-1-ol

: 98-59-9
p-toluenesulfonyl chloride

: 104946-84-1
(3R*,4S*)-3-<3-<3-(p-toluenesulfonyloxy)propyl>-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

Guidance literature:: With pyridine; at 0 ℃; for 8h;
DOI:10.1021/jm00384a026

Reference yield: 90.0%

: 1074-82-4
potassium phtalimide

: 104946-84-1
(3R*,4S*)-3-<3-<3-(p-toluenesulfonyloxy)propyl>-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

: 104946-85-2
(3R*,4S*)-3-<3-(3-phthalimidopropyl)-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

Guidance literature:: In N,N-dimethyl-formamide; at 70 ℃; for 3h;
DOI:10.1021/jm00384a026

Reference yield:

: 104946-84-1
(3R*,4S*)-3-<3-<3-(p-toluenesulfonyloxy)propyl>-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

: 104946-94-3
(3R*,4S*)-3-<3-<3-(aminophthalimido)propyl>-4-hydroxyphenyl>-4-(4-hydroxyphenyl)hexane

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / dimethylformamide / 3 h / 70 °C

2: 100 percent / hydrazine hydrate / ethanol / 48 h / 25 °C

3: 82 percent / AcOH / 3 h / Heating

4: 83 percent / H₂ / 5percent Pd/C / acetic acid / 3 h / 25 °C / 760 Torr

With hydrogen; hydrazine hydrate; acetic acid; palladium on activated charcoal; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026