Ethyl 2-amino-5-methylthiophene-3-carboxylate

Base Information

Chemical Name:Ethyl 2-amino-5-methylthiophene-3-carboxylate
CAS No.:4815-32-1
Molecular Formula:C8H11NO2S
Molecular Weight:185.247
Hs Code.:29349990
European Community (EC) Number:811-044-2
DSSTox Substance ID:DTXSID60398910
Nikkaji Number:J2.106.365G
Wikidata:Q72439780
Mol file:4815-32-1.mol

Synonyms:ethyl 2-amino-5-methylthiophene-3-carboxylate;4815-32-1;2-Amino-5-methyl-thiophene-3-carboxylic acid ethyl ester;Ethyl 2-amino-5-methyl-3-thiophenecarboxylate;MFCD01922142;2-amino-5-methylthiophene-3-carboxylic acid ethyl ester;3-THIOPHENECARBOXYLIC ACID, 2-AMINO-5-METHYL-, ETHYL ESTER;Ethyl2-amino-5-methyl-3-thiophenecarboxylate;Ethyl 2-amino-5-methyl-thiophene-3-carboxylate;SCHEMBL69313;2-Amino-5-Methyl-Thiophene-3-CarboxylicAcidEthylEster;DTXSID60398910;AYBUNZGJQVYGTM-UHFFFAOYSA-N;BBL015794;STK348633;AKOS000104107;CS-W016945;AC-28063;AM803944;AS-70140;2-amino-5-methyl-3-ethoxycarbonylthiophene;2-Amino-5-methyl-3-ethoxycarbonyl-thiophene;A7329;BB 0217642;E1104;ethyl2-amino-5-methylthiophene-3-carboxylate;FT-0678509;EN300-38951;ethyl 2-azanyl-5-methyl-thiophene-3-carboxylate;A827488;J-521303;2-amino-5-methyl-3-thiophenecarboxylic acid ethyl ester;2-amino-5-methyl-3-thiophenecarboxylic acid, ethyl ester;Z274567874

Suppliers and Price of Ethyl 2-amino-5-methylthiophene-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl 2-Amino-5-methylthiophene-3-carboxylate
50mg
$ 45.00

TRC
Ethyl 2-Amino-5-methylthiophene-3-carboxylate
100mg
$ 60.00

TCI Chemical
Ethyl 2-Amino-5-methylthiophene-3-carboxylate >98.0%(GC)
5g
$ 533.00

TCI Chemical
Ethyl 2-Amino-5-methylthiophene-3-carboxylate >98.0%(GC)
1g
$ 147.00

Matrix Scientific
Ethyl 2-amino-5-methylthiophene-3-carboxylate
1g
$ 89.00

Matrix Scientific
Ethyl 2-amino-5-methylthiophene-3-carboxylate
500mg
$ 58.00

Matrix Scientific
Ethyl 2-amino-5-methylthiophene-3-carboxylate
5g
$ 311.00

Crysdot
Ethyl 2-Amino-5-methylthiophene-3-carboxylate 97%
1g
$ 70.00

Crysdot
Ethyl 2-Amino-5-methylthiophene-3-carboxylate 97%
5g
$ 210.00

Crysdot
Ethyl 2-Amino-5-methylthiophene-3-carboxylate 97%
10g
$ 340.00

Total 40 raw suppliers

Chemical Property of Ethyl 2-amino-5-methylthiophene-3-carboxylate

Chemical Property:

Vapor Pressure:0.00182mmHg at 25°C
Melting Point:47.0 to 51.0 °C
Refractive Index:1.573
Boiling Point:292.6 °C at 760 mmHg
PKA:0.43±0.10(Predicted)
Flash Point:130.7 °C
PSA：80.56000
Density:1.219 g/cm³
LogP:2.39660
Storage Temp.:2-8°C(protect from light)
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:185.05104977
Heavy Atom Count:12
Complexity:174

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl 2-Amino-5-methylthiophene-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 20/21/22
Safety Statements: 3/7-36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(SC(=C1)C)N
Uses Ethyl 2-amino-5-methylthiophene-3-carboxylate is a useful intermediate for the Gewald synthesis of 2-aminothiophenes.

Technology Process of Ethyl 2-amino-5-methylthiophene-3-carboxylate

There total 5 articles about Ethyl 2-amino-5-methylthiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 123-38-6
propionaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 4815-32-1
ethyl 2-amino-5-methylthiophene-3-carboxylate

Guidance literature:: With octasulfur; triethylamine; In DMF (N,N-dimethyl-formamide); ethanol; at 20 - 60 ℃;

Reference yield: 48.6%

: 144918-37-6,56569-41-6
1-cyano-1-ethoxycarbonyl-1-butene

: 4815-32-1
ethyl 2-amino-5-methylthiophene-3-carboxylate

Guidance literature:: With morpholine; sulfur; In ethanol; for 2h; Heating / reflux;

Reference yield:

: 123-72-8
butyraldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 4815-32-1
ethyl 2-amino-5-methylthiophene-3-carboxylate

Guidance literature:: ethyl 2-cyanoacetate; With sulfur; triethylamine; In N,N-dimethyl-formamide; at 15 ℃; for 0.25h;

butyraldehyde; In N,N-dimethyl-formamide; for 3h;