N-[(2S,3R,4S,5S,6R)-5-((2R,4aR,6S,7R,8S,8aS)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-4-hydroxy-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl]-acetamide

Base Information

Chemical Name:N-[(2S,3R,4S,5S,6R)-5-((2R,4aR,6S,7R,8S,8aS)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-4-hydroxy-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl]-acetamide
CAS No.:146691-46-5
Molecular Formula:C₄₈H₅₀N₂O₁₀S
Molecular Weight:846.998
Hs Code.:

N-[(2S,3R,4S,5S,6R)-5-((2R,4aR,6S,7R,8S,8aS)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-4-hydroxy-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl]-acetamide

Synonyms:N-[(2S,3R,4S,5S,6R)-5-((2R,4aR,6S,7R,8S,8aS)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-4-hydroxy-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl]-acetamide

Suppliers and Price of N-[(2S,3R,4S,5S,6R)-5-((2R,4aR,6S,7R,8S,8aS)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-4-hydroxy-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl]-acetamide

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Chemical Property of N-[(2S,3R,4S,5S,6R)-5-((2R,4aR,6S,7R,8S,8aS)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-4-hydroxy-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl]-acetamide

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Technology Process of N-[(2S,3R,4S,5S,6R)-5-((2R,4aR,6S,7R,8S,8aS)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-4-hydroxy-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl]-acetamide

There total 8 articles about N-[(2S,3R,4S,5S,6R)-5-((2R,4aR,6S,7R,8S,8aS)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-4-hydroxy-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: Methanesulfonic acid (2S,3R,4R,5R,6R)-3-acetylamino-5-((2R,4aR,6S,7R,8R,8aR)-7-acetylamino-8-methanesulfonyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-4-yl ester

: 146691-46-5
N-[(2S,3R,4S,5S,6R)-5-((2R,4aR,6S,7R,8S,8aS)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-4-hydroxy-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl]-acetamide

Guidance literature:: With sodium acetate; In 2-methoxy-ethanol; water;
DOI:10.1016/S0040-4039(00)60825-0

Reference yield:

: 4551-15-9
phenylthiotrimethylsilane

: 146691-46-5
N-[(2S,3R,4S,5S,6R)-5-((2R,4aR,6S,7R,8S,8aS)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-4-hydroxy-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / ZnI₂ / 1,2-dichloro-ethane / 50 °C

2: sodium methoxide, methanol / CH₂Cl₂

3: p-toluenesulfonic acid / dimethylformamide

4: pyridine / dimethylformamide

5: 92 percent / pyridine

6: 82 percent / sodium acetate / 2-methoxy-ethanol; H₂O

With pyridine; methanol; sodium methylate; sodium acetate; toluene-4-sulfonic acid; zinc(II) iodide; In dichloromethane; 2-methoxy-ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)60825-0

Reference yield:

: 14814-46-1
β-S-Phenyl-di-N-acetyl-chitobiose

: 146691-46-5
N-[(2S,3R,4S,5S,6R)-5-((2R,4aR,6S,7R,8S,8aS)-7-Acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-4-hydroxy-2-phenylsulfanyl-6-trityloxymethyl-tetrahydro-pyran-3-yl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: p-toluenesulfonic acid / dimethylformamide

2: pyridine / dimethylformamide

3: 92 percent / pyridine

4: 82 percent / sodium acetate / 2-methoxy-ethanol; H₂O

With pyridine; sodium acetate; toluene-4-sulfonic acid; In 2-methoxy-ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)60825-0