methyl (S)-2-(5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxamido)-4-(dimethylamino)-2-methylbutanoate

Base Information

Chemical Name:methyl (S)-2-(5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxamido)-4-(dimethylamino)-2-methylbutanoate
CAS No.:914467-10-0
Molecular Formula:C₂₆H₃₂F₂N₄O₄
Molecular Weight:502.561
Hs Code.:

Synonyms:methyl (S)-2-(5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxamido)-4-(dimethylamino)-2-methylbutanoate

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Chemical Property of methyl (S)-2-(5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxamido)-4-(dimethylamino)-2-methylbutanoate

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Technology Process of methyl (S)-2-(5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxamido)-4-(dimethylamino)-2-methylbutanoate

There total 1 articles about methyl (S)-2-(5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxamido)-4-(dimethylamino)-2-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.1%

: 914467-28-0
5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 914467-18-8
methyl (S)-2-amino-4-(dimethylamino)-2-methylbutanoate

: 4070-48-8,18869-42-6,21685-47-2
D-Valine methyl ester

: 914467-10-0
methyl (S)-2-(5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxamido)-4-(dimethylamino)-2-methylbutanoate

: C₂₄H₂₇F₂N₃O₄

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield: 58.0%

: 914467-10-0
methyl (S)-2-(5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxamido)-4-(dimethylamino)-2-methylbutanoate

: (S)-5-(2,4-difluorophenoxy)-N-(4-(dimethylamino)-1-hydroxy-2-methylbutan-2-yl)-1-isobutyl-1H-indazole-6-carboxamide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 5h; Heating / reflux;

Reference yield:

: 914467-10-0
methyl (S)-2-(5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxamido)-4-(dimethylamino)-2-methylbutanoate

: 914467-26-8
C₂₅H₃₀F₂N₄O₄

Guidance literature:: methyl (S)-2-(5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxamido)-4-(dimethylamino)-2-methylbutanoate; With potassium trimethylsilonate; In tetrahydrofuran; at 20 ℃; for 24h;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 1h;