(R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid ethylmethylamide

Base Information

Chemical Name:(R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid ethylmethylamide
CAS No.:1586033-71-7
Molecular Formula:C₁₈H₂₇N₃OSn
Molecular Weight:420.142
Hs Code.:

Synonyms:(R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid ethylmethylamide

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Chemical Property of (R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid ethylmethylamide

Chemical Property:

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Technology Process of (R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid ethylmethylamide

There total 10 articles about (R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid ethylmethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.5%

: 1586033-70-6
(R)-1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylic acid ethylmethylamide

: 661-69-8
hexamethyldistannane

: 1586033-71-7
(R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid ethylmethylamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; Reflux;

Reference yield:

: 1586033-68-2
N-(α-methyl-4-iodobenzyl)-2-mercaptoimidazole-5-carboxylic acid methyl ester

: 1586033-71-7
(R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid ethylmethylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium nitrite; nitric acid / water; tetrachloromethane / 35 - 50 °C

2.1: sodium hydroxide / 5 h / Reflux

3.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 0.08 h / 20 °C

3.2: 48 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / Reflux

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; nitric acid; triethylamine; triphenylphosphine; sodium hydroxide; sodium nitrite; In tetrachloromethane; dichloromethane; water; toluene;

Reference yield:

: 1586033-65-9
N-(α-methyl-4-iodobenzyl)-N-formylglycine methyl ester

: 1586033-71-7
(R)-1-[1-(4-trimethylstannylphenyl)ethyl]-1H-imidazole-5-carboxylic acid ethylmethylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / toluene / 16 h / 20 °C / Cooling

2.1: hydrogenchloride / water; methanol / 2 h / 60 °C

3.1: sodium nitrite; nitric acid / water; tetrachloromethane / 35 - 50 °C

4.1: sodium hydroxide / 5 h / Reflux

5.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 0.08 h / 20 °C

5.2: 48 h / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / Reflux

With 1H-imidazole; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; nitric acid; sodium methylate; triethylamine; triphenylphosphine; sodium hydroxide; sodium nitrite; In methanol; tetrachloromethane; dichloromethane; water; toluene;