2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3-chloro-4-fluorophenyl)acetamide

Base Information

Chemical Name:2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3-chloro-4-fluorophenyl)acetamide
CAS No.:1385049-66-0
Molecular Formula:C₂₀H₁₆ClFN₂O₆
Molecular Weight:434.808
Hs Code.:

Synonyms:2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3-chloro-4-fluorophenyl)acetamide

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Chemical Property of 2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3-chloro-4-fluorophenyl)acetamide

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Technology Process of 2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3-chloro-4-fluorophenyl)acetamide

There total 3 articles about 2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3-chloro-4-fluorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.6%

: 1342848-44-5
C₈H₆ClFINO

: 1385049-56-8
N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen-3-yl)acetamide

: 1385049-66-0
2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3-chloro-4-fluorophenyl)acetamide

Guidance literature:: With potassium carbonate; In acetone; for 2h; Reflux;
DOI:10.1016/j.bmcl.2012.06.014

Reference yield:

: 4460-86-0,14374-62-0
asaraldehyde

: 1385049-66-0
2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3-chloro-4-fluorophenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / 24 h / 20 °C

2: sodium acetate / 4 h / Reflux

3: methanol; potassium carbonate / 0.5 h / Reflux

4: potassium carbonate / acetone / 2 h / Reflux

With methanol; aluminum (III) chloride; sodium acetate; potassium carbonate; In dichloromethane; acetone;
DOI:10.1016/j.bmcl.2012.06.014

Reference yield:

: 1385049-55-7
3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yl acetate

: 1385049-66-0
2-(3-acetamido-6-methoxy-2-oxo-2H-chromen-7-yloxy)-N-(3-chloro-4-fluorophenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; potassium carbonate / 0.5 h / Reflux

2: potassium carbonate / acetone / 2 h / Reflux

With methanol; potassium carbonate; In acetone;
DOI:10.1016/j.bmcl.2012.06.014