N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide

Base Information

Chemical Name:N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide
CAS No.:1620014-24-5
Molecular Formula:C₂₉H₂₉F₆N₅O₃
Molecular Weight:609.571
Hs Code.:

N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide

Synonyms:N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide

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Chemical Property of N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide

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Technology Process of N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide

There total 19 articles about N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₃₇F₆N₅O₅

: 1620014-24-5
N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 0.333333h;

Reference yield:

: 533-37-9
2,3-cyclopentenopyridine

: 1620014-24-5
N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 13 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 - 30 °C

2: trichlorophosphate / 3 h / 120 °C

3: sodium methylate / 18 h / 110 °C / Sealed tube

4: sulfuric acid; potassium nitrate / 4 h / 0 - 80 °C

5: hydrogen bromide; acetic acid / water / 0.67 h / 130 °C / Sealed tube

6: trichlorophosphate / 2 h / 110 °C / Sealed tube; Inert atmosphere

7: N-ethyl-N,N-diisopropylamine / butan-1-ol / 6 h / 150 °C

8: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 13 h / 20 - 30 °C

9: 1 h / 90 °C

10: iron; acetic acid / 3 h / 20 - 30 °C

11: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 - 30 °C

12: water; sodium hydroxide / tetrahydrofuran; methanol / 0.5 h / 20 - 30 °C

13: hydrogenchloride / 1,4-dioxane / 0.33 h

With hydrogenchloride; sulfuric acid; water; hydrogen bromide; sodium methylate; iron; acetic acid; potassium nitrate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 90685-58-8
6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide

: 1620014-24-5
N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1: trichlorophosphate / 3 h / 120 °C

2: sodium methylate / 18 h / 110 °C / Sealed tube

3: sulfuric acid; potassium nitrate / 4 h / 0 - 80 °C

4: hydrogen bromide; acetic acid / water / 0.67 h / 130 °C / Sealed tube

5: trichlorophosphate / 2 h / 110 °C / Sealed tube; Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / butan-1-ol / 6 h / 150 °C

7: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 13 h / 20 - 30 °C

8: 1 h / 90 °C

9: iron; acetic acid / 3 h / 20 - 30 °C

10: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 - 30 °C

11: water; sodium hydroxide / tetrahydrofuran; methanol / 0.5 h / 20 - 30 °C

12: hydrogenchloride / 1,4-dioxane / 0.33 h

With hydrogenchloride; sulfuric acid; water; hydrogen bromide; sodium methylate; iron; acetic acid; potassium nitrate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; butan-1-ol;