5-(((3S)-4-(4-(ethylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Base Information

Chemical Name:5-(((3S)-4-(4-(ethylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine
CAS No.:1572927-63-9
Molecular Formula:C₂₀H₂₄N₄O₄S₂
Molecular Weight:448.567
Hs Code.:

Synonyms:5-(((3S)-4-(4-(ethylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

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Chemical Property of 5-(((3S)-4-(4-(ethylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

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Technology Process of 5-(((3S)-4-(4-(ethylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

There total 10 articles about 5-(((3S)-4-(4-(ethylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572928-32-5
tert-butyl (5-(((3S)-4-(4-(ethylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

: 1572927-63-9
5-(((3S)-4-(4-(ethylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 1572928-30-3
(2S)-4-benzyl-1-(4-(ethylsulfonyl)phenyl)-2-(1-propyn-1-yl)piperazine

: 1572927-63-9
5-(((3S)-4-(4-(ethylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 12 h / 0 - 20 °C

1.2: 2 h / 80 °C

2.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1450621-78-9
(3S)-1-benzyl-3-(2-propyn-1-yl)-2,5-piperazinedione

: 1572927-63-9
5-(((3S)-4-(4-(ethylsulfonyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 80 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

3.1: 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 12 h / 20 - 100 °C / Inert atmosphere

4.1: potassium carbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 12 h / 0 - 20 °C

4.2: 2 h / 80 °C

5.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; potassium carbonate; triethylamine; trifluoroacetic acid; sodium t-butanolate; 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;