sodium 4'-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3'-hydroxybiphenyl-4-sulfonate

Base Information

Chemical Name:sodium 4'-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3'-hydroxybiphenyl-4-sulfonate
CAS No.:852204-69-4
Molecular Formula:C₃₀H₂₅FNO₆S*Na
Molecular Weight:569.586
Hs Code.:

Synonyms:sodium 4'-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3'-hydroxybiphenyl-4-sulfonate

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Chemical Property of sodium 4'-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3'-hydroxybiphenyl-4-sulfonate

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Technology Process of sodium 4'-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3'-hydroxybiphenyl-4-sulfonate

There total 7 articles about sodium 4'-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3'-hydroxybiphenyl-4-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: C₃₃H₂₇F₄NO₆S

: 852204-69-4
sodium 4'-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3'-hydroxybiphenyl-4-sulfonate

Guidance literature:: C₃₃H₂₇F₄NO₆S; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 0.25h;

Reference yield:

: C₃₁H₂₈FNO₅S

: 852204-69-4
sodium 4'-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3'-hydroxybiphenyl-4-sulfonate

Guidance literature:: C₃₁H₂₈FNO₅S; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 0.25h;

With triethylamine; In dichloromethane;

Reference yield:

: 852204-22-9
5-bromo-2-{(2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxo-1-phenylazetidin-2-yl}phenyl acetate

: 852204-69-4
sodium 4'-{(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-1-phenylazetidin-2-yl}-3'-hydroxybiphenyl-4-sulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / bis(1-adamantylamine)palladium⁽⁰⁾ / 1,4-dioxane / 4 h / 80 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

3.1: dichloromethane / 8.5 h / 20 °C

4.1: triethylamine / methanol; water / 2.75 h

5.1: hydrogen fluoride / acetonitrile / 4 h / 20 °C

5.2: pH 7.4 phosphate buffer / pH 8

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.25 h / 20 °C

6.2: Dowex_.(R). sodium ion exchange resin

With hydrogen fluoride; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; bis(1-adamantylamine)palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile; 3.1: Pummerer Reaction;