Technology Process of C25H21F4NO5
There total 9 articles about C25H21F4NO5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-bromoethyl acetate;
With
potassium carbonate;
In
N,N-dimethyl acetamide;
at 20 - 30 ℃;
for 1.5h;
Inert atmosphere;
2-[2,4-difluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy] acetic acid;
In
N,N-dimethyl acetamide;
at 30 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 3 h / 20 °C
2.1: borane-THF / tetrahydrofuran / 2 h / 0 - 60 °C
3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 60 °C
4.1: potassium carbonate / N,N-dimethyl acetamide / 1.5 h / 20 - 30 °C / Inert atmosphere
4.2: 1 h / 30 °C
With
borane-THF; lithium hydroxide monohydrate; water; potassium carbonate; triethylamine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium carbonate / N,N-dimethyl-formamide / 0.67 h / 20 °C
2.1: triethylamine / dichloromethane / 3 h / 20 °C
3.1: borane-THF / tetrahydrofuran / 2 h / 0 - 60 °C
4.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 60 °C
5.1: potassium carbonate / N,N-dimethyl acetamide / 1.5 h / 20 - 30 °C / Inert atmosphere
5.2: 1 h / 30 °C
With
borane-THF; lithium hydroxide monohydrate; water; sodium carbonate; potassium carbonate; triethylamine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
