4-benzoyl-1-methyl-5-hydroxy-3-trifluoromethylpyrazole

Base Information

Chemical Name:4-benzoyl-1-methyl-5-hydroxy-3-trifluoromethylpyrazole
CAS No.:211256-77-8
Molecular Formula:C₁₂H₉F₃N₂O₂
Molecular Weight:270.211
Hs Code.:

Synonyms:4-benzoyl-1-methyl-5-hydroxy-3-trifluoromethylpyrazole

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Chemical Property of 4-benzoyl-1-methyl-5-hydroxy-3-trifluoromethylpyrazole

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Technology Process of 4-benzoyl-1-methyl-5-hydroxy-3-trifluoromethylpyrazole

There total 3 articles about 4-benzoyl-1-methyl-5-hydroxy-3-trifluoromethylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 211256-74-5
4-bromo-5-benzoyloxy-1-methyl-3-trifluoromethylpyrazole

: 211256-77-8
4-benzoyl-1-methyl-5-hydroxy-3-trifluoromethylpyrazole

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; for 3h; Heating;
DOI:10.1080/00397919808007030

Reference yield:

: 122431-37-2
2-methyl-5-trifluoromethyl-2H-pyrazol-3-ol

: 211256-77-8
4-benzoyl-1-methyl-5-hydroxy-3-trifluoromethylpyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / NBS / CHCl₃ / 1 h / -5 °C

2: 90 percent / Et₃N / CHCl₃ / 1 h / 0 - 20 °C

3: 76 percent / t-butyllithium / tetrahydrofuran / 3 h / Heating

With N-Bromosuccinimide; tert.-butyl lithium; triethylamine; In tetrahydrofuran; chloroform; 1: Bromination / 2: Esterification / 3: Rearrangement;
DOI:10.1080/00397919808007030

Reference yield:

: 122431-43-0
4-bromo-1-methyl-5-hydroxypyrazole

: 211256-77-8
4-benzoyl-1-methyl-5-hydroxy-3-trifluoromethylpyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N / CHCl₃ / 1 h / 0 - 20 °C

2: 76 percent / t-butyllithium / tetrahydrofuran / 3 h / Heating

With tert.-butyl lithium; triethylamine; In tetrahydrofuran; chloroform; 1: Esterification / 2: Rearrangement;
DOI:10.1080/00397919808007030