tert-butyl (2S)-benzenesulfonylamino-3-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Base Information

Chemical Name:tert-butyl (2S)-benzenesulfonylamino-3-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate
CAS No.:247033-63-2
Molecular Formula:C₂₉H₃₆N₆O₅S
Molecular Weight:580.708
Hs Code.:

Synonyms:tert-butyl (2S)-benzenesulfonylamino-3-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Suppliers and Price of tert-butyl (2S)-benzenesulfonylamino-3-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (2S)-benzenesulfonylamino-3-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2S)-benzenesulfonylamino-3-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

There total 8 articles about tert-butyl (2S)-benzenesulfonylamino-3-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 247034-90-8
4-{4-(Pyrimidin-2-ylamino)piperidin-1-yl}benzoic acid

: tert-butyl (2S)-N-benzenesulfonyl-2,3-diaminopropionate hydrochloride

: 247033-63-2
tert-butyl (2S)-benzenesulfonylamino-3-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Guidance literature:: 4-{4-(Pyrimidin-2-ylamino)piperidin-1-yl}benzoic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h;

tert-butyl (2S)-N-benzenesulfonyl-2,3-diaminopropionate hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at -10 ℃; for 2h;
DOI:10.1016/j.bmc.2005.10.060

Reference yield:

: t-butyl (2S)-N-benzenesulfonyl-2,3-diaminopropionate hydrochloride

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

: 247033-63-2
tert-butyl (2S)-benzenesulfonylamino-3-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N-methyl-acetamide; dichloromethane;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 247033-63-2
tert-butyl (2S)-benzenesulfonylamino-3-[4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 77 percent / dimethylsulfoxide / 72 h / 120 °C

2.1: 51 percent / P(n-Bu)3; 1,1'-(azodicarbonyl)dipiperidine / benzene / 23 h / 0 - 20 °C

3.1: 99 percent / hydrazine monohydrate / methanol / 16 h / 20 °C

4.1: 64 percent / (i-Pr)2NEt / dimethylformamide / 10 h / 125 °C

5.1: 82 percent / NaOH / methanol; tetrahydrofuran; H₂O / 8 h / 40 °C

6.1: (i-Pr)2NEt; BOP / dimethylformamide; CH₂Cl₂ / 3 h / 20 °C

6.2: 60 percent / (i-Pr)2NEt / dimethylformamide; CH₂Cl₂ / 2 h / -10 °C

With sodium hydroxide; tributylphosphine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.bmc.2005.10.061