Technology Process of (1S,2S,3S,4S)-1-(2',2',2'-trichloromethylcarbonylamino)-2,3,4-trihydroxycyclohexane
There total 10 articles about (1S,2S,3S,4S)-1-(2',2',2'-trichloromethylcarbonylamino)-2,3,4-trihydroxycyclohexane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; sodium hydrogencarbonate; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; water; tert-butyl alcohol;
at 20 ℃;
for 24h;
DOI:10.1039/c0ob00619j
- Guidance literature:
-
(1S,2R)-1-(2',2',2'-trichloromethylcarbonylamino)-2-hydroxycyclohex-3-ene;
With
osmium(VIII) oxide; N,N,N,N,-tetramethylethylenediamine;
In
dichloromethane;
at -78 - 20 ℃;
for 2h;
Inert atmosphere;
With
hydrogenchloride;
In
methanol; water;
for 2h;
DOI:10.1039/c0ob00619j
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Grubbs catalyst first generation / dichloromethane / 65 °C
2.1: N-iodo-succinimide / chloroform / 18 h / Inert atmosphere
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 12 h / Reflux; Inert atmosphere
4.1: hydrogenchloride; water / methanol / 1 h / 20 °C
5.1: osmium(VIII) oxide; N,N,N,N,-tetramethylethylenediamine / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere
5.2: 2 h
With
Grubbs catalyst first generation; hydrogenchloride; N-iodo-succinimide; osmium(VIII) oxide; N,N,N,N,-tetramethylethylenediamine; water; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol; dichloromethane; chloroform; toluene;
DOI:10.1039/c0ob00619j
