C₄₄H₄₄N₂

Base Information

Chemical Name:C₄₄H₄₄N₂
CAS No.:1273586-88-1
Molecular Formula:C₄₄H₄₄N₂
Molecular Weight:600.847
Hs Code.:

C<sub>44</sub>H<sub>44</sub>N<sub>2</sub>

Synonyms:C₄₄H₄₄N₂

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Chemical Property of C₄₄H₄₄N₂

Chemical Property:

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Technology Process of C₄₄H₄₄N₂

There total 8 articles about C₄₄H₄₄N₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1273586-87-0
3-bromo-1-hexyl-2-(phenylethynyl)-1H-indole

: 1273586-88-1
C₄₄H₄₄N₂

Guidance literature:: 3-bromo-1-hexyl-2-(phenylethynyl)-1H-indole; With caesium carbonate; hydroquinone; cesium fluoride; In 1,4-dioxane; for 0.333333h; Inert atmosphere;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In 1,4-dioxane; hexane; at 130 - 140 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol200213h

Reference yield:

: 120-72-9
indole

: 1273586-88-1
C₄₄H₄₄N₂

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide

2.1: bromine / dichloromethane / 4.5 h / 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: water; sodium hydroxide / methanol / 85 °C / Inert atmosphere

5.1: potassium hydroxide / N,N-dimethyl-formamide / 1 h

5.2: 50 °C

6.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 13 h / 50 °C / Inert atmosphere

7.1: caesium carbonate; hydroquinone; cesium fluoride / 1,4-dioxane / 0.33 h / Inert atmosphere

7.2: 24 h / 130 - 140 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; bromine; caesium carbonate; diethylamine; hydroquinone; cesium fluoride; potassium hydroxide; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 6.1: Sonogashira coupling;
DOI:10.1021/ol200213h

Reference yield:

: 111-25-1
1-bromo-hexane

: 1273586-88-1
C₄₄H₄₄N₂

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide / 1 h

1.2: 50 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 13 h / 50 °C / Inert atmosphere

3.1: caesium carbonate; hydroquinone; cesium fluoride / 1,4-dioxane / 0.33 h / Inert atmosphere

3.2: 24 h / 130 - 140 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; caesium carbonate; diethylamine; hydroquinone; cesium fluoride; potassium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; 2.1: Sonogashira coupling;
DOI:10.1021/ol200213h