methyl (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}-2-butenoate

Base Information

Chemical Name:methyl (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}-2-butenoate
CAS No.:1360540-43-7
Molecular Formula:C₃₀H₂₂ClF₄NO₅
Molecular Weight:587.955
Hs Code.:

Synonyms:methyl (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}-2-butenoate

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Chemical Property of methyl (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}-2-butenoate

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Technology Process of methyl (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}-2-butenoate

There total 8 articles about methyl (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 391687-64-2
2-[4-(3-bromophenyl)-7-chloro-6-methyl-2-oxo-2H-chromen-3-yl]-N-[4-fluoro-2-(trifluoromethyl)phenyl]acetamide

: 623-43-8
crotonic acid methyl ester

: 1360540-43-7
methyl (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}-2-butenoate

Guidance literature:: With palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 120 ℃; for 5h; Inert atmosphere;
DOI:10.1248/cpb.59.1369

Reference yield:

: C₁₈H₁₁BrCl₂O₃

: 1360540-43-7
methyl (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}-2-butenoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C

2: palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere

With palladium diacetate; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Heck reaction;
DOI:10.1248/cpb.59.1369

Reference yield:

: [4-(3-bromophenyl)-7-chloro-6-methyl-2-oxo-2H-chromen-3-yl]acetic acid

: 1360540-43-7
methyl (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}-2-butenoate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

2: tetrahydrofuran / 20 °C

3: palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 5 h / 120 °C / Inert atmosphere

With oxalyl dichloride; palladium diacetate; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 3: Heck reaction;
DOI:10.1248/cpb.59.1369