2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(methylsulfonyl)phenoxy)methyl)thiazole

Base Information

Chemical Name:2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(methylsulfonyl)phenoxy)methyl)thiazole
CAS No.:1361391-27-6
Molecular Formula:C₂₃H₂₇N₃O₄S₂
Molecular Weight:473.617
Hs Code.:

Synonyms:2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(methylsulfonyl)phenoxy)methyl)thiazole

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Chemical Property of 2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(methylsulfonyl)phenoxy)methyl)thiazole

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Technology Process of 2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(methylsulfonyl)phenoxy)methyl)thiazole

There total 4 articles about 2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(methylsulfonyl)phenoxy)methyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 14763-60-1
4-methanesulfonyl-phenol

: 1361391-35-6
4-(chloromethyl)-2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl) thiazole

: 1361391-27-6
2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(methylsulfonyl)phenoxy)methyl)thiazole

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield:

: 1361391-32-3
4-(5-ethylpyrimidin-2-yloxy)cyclohexanecarbothioamide

: 1361391-27-6
2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(methylsulfonyl)phenoxy)methyl)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium sulfate / acetone / 15 h / Reflux

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 3 h / 80 °C

With magnesium sulfate; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetone;

Reference yield:

: 1361391-29-8
4-(5-ethylpyrimidin-2-yloxy)cyclohexanecarbonitrile

: 1361391-27-6
2-(4-(5-ethylpyrimidin-2-yloxy)cyclohexyl)-4-((4-(methylsulfonyl)phenoxy)methyl)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1: tetraphosphorus decasulfide / ethanol / 3 h / Reflux

2: magnesium sulfate / acetone / 15 h / Reflux

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 3 h / 80 °C

With tetraphosphorus decasulfide; magnesium sulfate; potassium carbonate; potassium iodide; In ethanol; N,N-dimethyl-formamide; acetone;