(2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylicacid

Base Information

• Chemical Name: (2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylicacid
• CAS No.: 960009-03-4
• Molecular Formula: C₁₄H₁₇NO₄S
• Molecular Weight: 295.359
• Mol file: 960009-03-4.mol

Synonyms:(2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylicacid

Chemical Property of (2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylicacid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylicacid

There total 10 articles about (2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (2S,3R,4R)-1-benzoyl-3-(tert-butoxycarbonylmethyl)-4-(4-methylphenylthio)pyrrolid ine-2-carboxylate (960009-04-5) → (2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylicacid (960009-03-4)

Guidance literature:

With hydrogenchloride; water; at 110 ℃; for 5h;

Reference yield:

C18H20F3NO5S → (2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylicacid (960009-03-4)

Guidance literature:

With water; sodium hydroxide; at 100 ℃; for 0.0166667h;

DOI:10.1016/j.bmcl.2011.02.018

Reference yield:

C23H29BF3NO7S (1290103-85-3) → (2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylicacid (960009-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 0.08 h / 100 °C

2: water; sodium hydroxide / 0.02 h / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; potassium carbonate; tris-(o-tolyl)phosphine; sodium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.02.018

upstream raw materials:

methyl (2S,3R,4R)-1-benzoyl-3-(tert-butoxycarbonylmethyl)-4-(4-methylphenylthio)pyrrolid ine-2-carboxylate

C₂₃H₂₉BF₃NO₇S

methyl (2S,3R,4R)-1-benzoyl-4-(4-bromophenylthio)-3-(tert-butoxycarbonylmethyl)pyrrolidine-2-carboxylate

C₁₃H₁₄BrNO₄S*ClH