Technology Process of N-(2-chlorobenzyl)-N-(2-oxo-2-phenylethyl)-O18-pivalamide
There total 4 articles about N-(2-chlorobenzyl)-N-(2-oxo-2-phenylethyl)-O18-pivalamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium carbonate; 18O-labeled water; palladium dichloride;
In
1,4-dioxane;
at 100 ℃;
for 14h;
Inert atmosphere;
DOI:10.1021/ol102634c
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triphenylphosphine / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere
2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium carbonate; 18O-labeled water; palladium dichloride / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium carbonate; 18O-labeled water; triphenylphosphine; palladium dichloride;
In
1,4-dioxane; dichloromethane;
DOI:10.1021/ol102634c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 14 h / Inert atmosphere; Reflux
2: triphenylphosphine / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere
3: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium carbonate; 18O-labeled water; palladium dichloride / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium carbonate; 18O-labeled water; triethylamine; triphenylphosphine; palladium dichloride;
In
1,4-dioxane; dichloromethane;
DOI:10.1021/ol102634c
