5-(4-nitrophenyl)-8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

Base Information

• Chemical Name: 5-(4-nitrophenyl)-8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
• CAS No.: 102771-27-7
• Molecular Formula: C₁₇H₁₃N₃O₄
• Molecular Weight: 323.308
• Mol file: 102771-27-7.mol

Synonyms:5-(4-nitrophenyl)-8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

Chemical Property of 5-(4-nitrophenyl)-8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-nitrophenyl)-8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

There total 6 articles about 5-(4-nitrophenyl)-8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-(4-nitrobenzoyl)-4,5-methylenedioxyphenylacetone (433716-67-7) → 5-(4-nitrophenyl)-8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine (102771-27-7)

Guidance literature:

With hydrazine hydrate; for 16h;

DOI:10.1246/bcsj.20150064

Reference yield: 50.0%

2-(4-nitrobenzoyl)-4,5-methylenedioxyphenylacetone (433716-67-7) → 3-methyl-6,7-methylenedioxy-1-(4-nitrophenyl)isoquinoline (433716-68-8) + 5-(4-nitrophenyl)-8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine (102771-27-7)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 2h;

DOI:10.1081/SCC-120002397

Reference yield:

6-(trimethylsilyl)benzo[d][1,3]dioxol-5-yl triflate (717903-52-1) → 5-(4-nitrophenyl)-8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine (102771-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1: cesium fluoride / acetonitrile / 15 h / 20 °C

2: hydrazine hydrate / ethanol / 16 h / 20 °C

With hydrazine hydrate; cesium fluoride; In ethanol; acetonitrile;

DOI:10.1246/cl.130580

upstream raw materials:

2-(4-nitrobenzoyl)-4,5-methylenedioxyphenylacetone

1-allyl-3,4-methylenedioxybenzene

β-oxy-α-(3',4'-methylenedioxyphenyl)propane

1-(1,3-benzodioxol-5-yl)-2-propanone

Downstream raw materials:

1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine

8-methyl-7-methylcarbamoyl-5-(4-nitrophenyl)-7H-1,3-dioxolo-/4,5-h//2,3/benzodiazepine

1-(4-Nitrophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine

GYKI 52895