L-aspartyl-L-m,p-dihydroxyphenylalanine methyl ester

Base Information

• Chemical Name: L-aspartyl-L-m,p-dihydroxyphenylalanine methyl ester
• CAS No.: 72683-73-9
• Molecular Formula: C₁₄H₁₈N₂O₇
• Molecular Weight: 326.306
• Mol file: 72683-73-9.mol

Synonyms:L-aspartyl-L-m,p-dihydroxyphenylalanine methyl ester

Chemical Property of L-aspartyl-L-m,p-dihydroxyphenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of L-aspartyl-L-m,p-dihydroxyphenylalanine methyl ester

There total 2 articles about L-aspartyl-L-m,p-dihydroxyphenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-L-m,p-dihydroxyphenylalanine methyl ester → L-aspartyl-L-m,p-dihydroxyphenylalanine methyl ester (72683-73-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 1h; under 2585.7 Torr; Ambient temperature;

DOI:10.1021/jm00178a013

Reference yield:

L-dopa methyl ester hydrochloride (1421-65-4) → L-aspartyl-L-m,p-dihydroxyphenylalanine methyl ester (72683-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / Et₃N, DCC / CH₂Cl₂ / 12 h / Ambient temperature

2: 69 percent / H₂ / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr / Ambient temperature

With hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; acetic acid;

DOI:10.1021/jm00178a013

upstream raw materials:

L-dopa methyl ester hydrochloride