2-(2-Methoxycarbonylanilino)-4-methylbenzoic acid

Base Information

Chemical Name:2-(2-Methoxycarbonylanilino)-4-methylbenzoic acid
CAS No.:112239-01-7
Molecular Formula:C₁₆H₁₅NO₄
Molecular Weight:285.299
Hs Code.:
DSSTox Substance ID:DTXSID701196130
Nikkaji Number:J786.755G

Synonyms:112239-01-7;DTXSID701196130;2-[[2-(Methoxycarbonyl)phenyl]amino]-4-methylbenzoic acid

Suppliers and Price of 2-(2-Methoxycarbonylanilino)-4-methylbenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-Methoxycarbonylanilino)-4-methylbenzoic acid

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:285.10010796
Heavy Atom Count:21
Complexity:385

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)C(=O)O)NC2=CC=CC=C2C(=O)OC

Technology Process of 2-(2-Methoxycarbonylanilino)-4-methylbenzoic acid

There total 1 articles about 2-(2-Methoxycarbonylanilino)-4-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 610-97-9
o-iodo-methyl-benzoic acid

4-methylanthranilic acid: 2305-36-4
4-methylanthranilic acid

: 112239-01-7
4-methyl-2-<<2-(methoxycarbonyl)phenyl>amino>benzoic acid

Guidance literature:: With N-ethylmorpholine;; copper; In various solvent(s); at 120 ℃; for 5h;

Reference yield:

: 112239-01-7
4-methyl-2-<<2-(methoxycarbonyl)phenyl>amino>benzoic acid

: 190845-22-8
2-(2-Hydroxymethyl-5-methyl-phenylamino)-benzoic acid methyl ester

Guidance literature:: With sodium tetrahydroborate; 1,1'-carbonyldiimidazole; Multistep reaction; 1.) THF, 15 h, 20 deg C, 2.) THF, H₂O, 20 deg C;
DOI:10.1016/S0040-4039(96)02396-9

Reference yield:

: 112239-01-7
4-methyl-2-<<2-(methoxycarbonyl)phenyl>amino>benzoic acid

: 188054-40-2
2-(2-Formyl-5-methyl-phenylamino)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 15 h / Ambient temperature

2: NaBH₄ / H₂O / 0.5 h

3: 100 percent / MnO₂ / acetone / 18 h / Heating

With manganese(IV) oxide; sodium tetrahydroborate; In tetrahydrofuran; water; acetone;
DOI:10.1021/jm970004n