Nitroaspirin

Base Information

Chemical Name:Nitroaspirin
CAS No.:175033-36-0
Deprecated CAS:190442-10-5
Molecular Formula:C16H13 N O7
Molecular Weight:331.282
Hs Code.:
UNII:EH04H13L6B
DSSTox Substance ID:DTXSID60938618
Wikidata:Q3877377
NCI Thesaurus Code:C61499
Metabolomics Workbench ID:153432
ChEMBL ID:CHEMBL374385
Mol file:175033-36-0.mol

Synonyms:2-acetoxybenzoate-2-(1-nitroxymethyl)phenyl ester;NCX 4016;NCX-4016;nitric oxide-releasing aspirin;nitroaspirin

Suppliers and Price of Nitroaspirin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NO-Aspirin1
50mg
$ 265.00

Sigma-Aldrich
NCX 4016 ≥98% (HPLC)
5mg
$ 90.30

Sigma-Aldrich
NCX 4016 ≥98% (HPLC)
25mg
$ 364.00

Medical Isotopes, Inc.
NO-Aspirin1 98%
125 mg
$ 1880.00

ChemScene
Nitroaspirin
5mg
$ 650.00

ChemScene
Nitroaspirin
10mg
$ 500.00

ChemScene
Nitroaspirin
50mg
$ 950.00

ChemScene
Nitroaspirin
100mg
$ 1600.00

American Custom Chemicals Corporation
[3-(NITROOXYMETHYL)PHENYL] 2-ACETYLOXYBENZOATE 95.00%
250MG
$ 1593.90

American Custom Chemicals Corporation
[3-(NITROOXYMETHYL)PHENYL] 2-ACETYLOXYBENZOATE 95.00%
25MG
$ 704.55

Total 55 raw suppliers

Chemical Property of Nitroaspirin

Chemical Property:

Vapor Pressure:4.21E-10mmHg at 25°C
Melting Point:61-62℃
Refractive Index:1.58
Boiling Point:499.3°Cat760mmHg
Flash Point:214.3°C
PSA：107.65000
Density:1.347g/cm³
LogP:3.06260
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly)
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:331.06920175
Heavy Atom Count:24
Complexity:462

Purity/Quality:

99%, ^*data from raw suppliers

NO-Aspirin1 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)OC1=CC=CC=C1C(=O)OC2=CC=CC(=C2)CO[N+](=O)[O-]
Recent ClinicalTrials:Renal and Systemic Effects of NCX4016 in Patients With Type 2 Diabetes and Early Nephropathy
Uses NO-Aspirin 1 is a hybrid molecule of aspirin and a nitric oxide (NO) donor. It contains an ester linkage, that when cleaved by esterases in the gut, liver, and plasma releases salicylate and an NO-releasing moiety. It also prevents restinosiis, inhibits proliferation of vascular smooth muscle cells, reduces infarct ssize following cardiac ischemia, and exhibits strong chemopreventative effects against colon cancer development.

Technology Process of Nitroaspirin

There total 6 articles about Nitroaspirin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%